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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 932296

Časopis

Autori: Terzic, Senka; Udikovic-Kolic, Nikolina; Jurina, Tamara; Krizman-Matasic, Ivona; Senta, Ivan; Mihaljevic, Ivan; Loncar, Jovica; Smital; Tvrtko; Ahel, Marijan
Naslov: Biotransformation of macrolide antibiotics using enriched activated sludge culture: Kinetics, transformation routes and ecotoxicological evaluation
( Biotransformation of macrolide antibiotics using enriched activated sludge culture: Kinetics, transformation routes and ecotoxicological evaluation )
Izvornik: Journal of hazardous materials (0304-3894) 349 (2018); 143-152
Vrsta rada: članak
Ključne riječi: Macrolide antibiotics ; Biodegradation: Biotransformation ; Transformation products ; Transformation pathway ; Ecotoxicological evaluation
( Macrolide antibiotics ; Biodegradation: Biotransformation ; Transformation products ; Transformation pathway ; Ecotoxicological evaluation )
Sažetak:
The biotransformation of three prominent macrolide antibiotics (azithromycin, clarithromycin and erythromycin) by an activated sludge culture, which was adapted to high concentrations of azithromycin (10 mg/L) was investigated. The study included determination of removal kinetics of the parent compounds, identification of their major biotransformation products (TPs) and assessment of ecotoxicological effects of biotransformation. The chemical analyses were performed by ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry, which enabled a tentative identification of TPs formed during the experiments. The ecotoxicological evaluation included two end-points, residual antibiotic activity and toxicity to freshwater algae. The enriched activated sludge culture was capable of degrading all studied macrolide compounds with high removal efficiencies (> 99%) of the parent compounds at elevated concentrations (10 mg/L). The elimination of all three macrolide antibiotics was associated with the formation of different TPs, including several novel compounds previously unreported in the literature. Some of the TPs were rather abundant and contributed significantly to the overall mass balance at the end of the biodegradation experiments. Biodegradation of all investigated macrolides was associated with a pronounced reduction of the residual antibiotic activity and algal toxicity, indicating a rather positive ecotoxicological outcome of the biotransformation processes achieved by the enriched sludge culture.
Projekt / tema: HRZZ-IP-2014-09-7031
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Interdisciplinarne prirodne znanosti
Puni text rada: 932296.Terzic_et_al_JHM_2018.pdf (tekst priložen 26. Ožu. 2018. u 14:49 sati)
URL Internet adrese: https://www.sciencedirect.com/science/article/pii/S0304389418300621
Broj citata:
Altmetric:
DOI: 10.1016/j.jhazmat.2018.01.055
URL cjelovitog teksta:
Google Scholar: Biotransformation of macrolide antibiotics using enriched activated sludge culture: Kinetics, transformation routes and ecotoxicological evaluation
Upisao u CROSBI: Ivan Senta (Ivan.Senta@irb.hr), 26. Ožu. 2018. u 14:49 sati



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