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Pregled bibliografske jedinice broj: 933709

Časopis

Autori: Štimac, Adela; Bendelja, Krešo; Dutour Sikirić, Maja; Frkanec, Leo; Frkanec, Ruža
Naslov: Mannosylated Liposomes with Built-in Peptidoglycan Based Immunomodulators for Subunit Vaccine Formulations
( Mannosylated Liposomes with Built-in Peptidoglycan Based Immunomodulators for Subunit Vaccine Formulations )
Izvornik: Croatica chemica acta (0011-1643) 90 (2017), 4; 645-656
Vrsta rada: članak
Ključne riječi: mannosylated liposomes ; targeted delivery ; peptidoglycan monomer ; adamantyltripeptide ; adjuvants ; subunit vaccines
( mannosylated liposomes ; targeted delivery ; peptidoglycan monomer ; adamantyltripeptide ; adjuvants ; subunit vaccines )
Sažetak:
The aim of the present study is preparation of mannosylated liposomes with built-in small molecule immunopotentiators for targeted, receptors mediated, delivery of antigens. The liposomes were mannosylated in two ways, by covalent attachment of p-aminophenyl-α-D- mannopyranoside to the preformed liposomes and by incorporation of synthetic mono-, di- and tetramannosyl-lipoconjugates into the lipid bilayer of liposomes. Four different mannosylated liposome formulations with incorporated model antigen, ovalbumin (OVA), and immunomodulators, PGM and Ad2TP2, were prepared and characterized. The influence of mannosylated liposome formulations on the antigen-specific humoral immune response was investigated. It has been shown that mannosylated liposomal formulations did not enhance the humoral immune response and production of anti-OVA antibodies but they significantly affected the type of OVA specific immune reaction and directed it towards Th1 type.
Projekt / tema: HRZZ-IP-2013-11-7387
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
URL Internet adrese: https://hrcak.srce.hr/197960
Broj citata:
Altmetric:
DOI: 10.5562/cca3309
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: NE
Google Scholar: Mannosylated Liposomes with Built-in Peptidoglycan Based Immunomodulators for Subunit Vaccine Formulations
Upisao u CROSBI: Adela Štimac (astimac@unizg.hr), 9. Tra. 2018. u 06:54 sati



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