Hrvatska znanstvena Sekcija img
3 gif
 O projektu
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 939762


Autori: Jazvinšćak Jembrek, Maja; Slade, Neda; Hof, Patrick R.; Šimić, Goran
Naslov: The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease
Izvornik: Progress in neurobiology (0301-0082) 168 (2018); 104-127
Vrsta rada: pregledni rad
Ključne riječi: p53 ; Aβ ; Tau ; Oxidative stress ; Neuronal apoptosis ; Alzheimer's disease
Alzheimer’s disease (AD), the most common progressive neurodegenerative disorder, is characterized by severe cognitive decline and personality changes as a result of synaptic and neuronal loss. The defining clinicopathological hallmarks of the disease are deposits of amyloid precursor protein (APP)-derived amyloid-β peptides (Aβ) in the brain parenchyma, and intracellular aggregates of truncated and hyperphosphorylated tau protein in neurofibrillary tangles (NFT). At the cellular and molecular levels, many intertwined pathological mechanisms that relate Aβ and tau pathology with a transcription factor p53 have been revealed. p53 is activated in response to various stressors that threaten genomic stability. Depending on damage severity, it promotes neuronal death or survival, predominantly via transcription-dependent mechanisms that affect expression of apoptosis-related target genes. Levels of p53 are enhanced in the AD brain and maintain sustained tau hyperphosphorylation, whereas intracellular Aβ directly contributes to p53 pool and promotes downstream p53 effects. The review summarizes the role of p53 in neuronal function, discusses the interactions of p53, tau, and Aβ in the normal brain and during the progression of AD pathology, and considers the impact of the most prominent hereditary risk factors of AD on p53/tau/Aβ interactions. A better understanding of this intricate interplay would provide deeper insight into AD pathology and might offer some novel therapeutic targets for the improvement of treatment options. In this regard, drugs and natural compounds targeting the p53 pathway are of growing interest in neuroprotection as they may represent promising therapeutic approaches in the prevention of oxidative stress-dependent pathological processes underlying AD.
Projekt / tema: HRZZ-IP-2014-09-9730, HRZZ-IP-11-2013-1615
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)
URL Internet adrese:
Broj citata:
DOI: 10.1016/j.pneurobio.2018.05.001
URL cjelovitog teksta:
Google Scholar: The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease
Upisao u CROSBI: Maja Jazvinšćak Jembrek (, 25. Svi. 2018. u 08:39 sati

  Verzija za printanje   za tiskati