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Emergence of colistin resistance in Enterobacter aerogenes from Croatia (CROSBI ID 252009)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bedenić, Branka ; Vranić-Ladavac, Mirna ; Venditti, Carolina ; Tambić-Andrašević, Arjana ; Barišić, Nada ; Gužvinec, Marija ; Karčić, Natalie ; Petrosillo, Nicola ; Ladavac, Ranko ; di Caro, Antonino Emergence of colistin resistance in Enterobacter aerogenes from Croatia // Journal of chemotherapy, 30 (2018), 2; 120-123. doi: 10.1080/1120009X.2017.1382121

Podaci o odgovornosti

Bedenić, Branka ; Vranić-Ladavac, Mirna ; Venditti, Carolina ; Tambić-Andrašević, Arjana ; Barišić, Nada ; Gužvinec, Marija ; Karčić, Natalie ; Petrosillo, Nicola ; Ladavac, Ranko ; di Caro, Antonino

engleski

Emergence of colistin resistance in Enterobacter aerogenes from Croatia

A colistin resistant Enterobacter aerogenes [study code 12264] was isolated from the tracheal aspirate of a 71-year old male patient in the General Hospital [GH] in Pula, Croatia. The patient was previously treated in University Hospital Center in Rijeka with colistin in order to eradicate Acinetobacter baumannii isolate, susceptible only to colistin and tigecycline. Genes encoding ESBLs [blaTEM, blaSHV, blaCTX-M, blaPER-1] were screened by PCR. The strain was shown to possess blaCTX-M-15 and blaTEM-1 genes. To asses genes possibly involved in resistance to colistin the chromosomal enconding mgrB gene and the plasmid-mediated mcr-1 and mcr-2 genes were screened as described previously. Mcr-1 and mcr-2 genes were not detected and mgrB gene presented a wild-type sequence. PCR-based Replicon typing method [PBRT] conducted on an E. aerogenes isolate, showed that the strain carried an IncN plasmid. Adaptive mechanisms such as changes of the bacterial cell outer membrane that cause porin decrease or presence of an efflux pump, due to selection pressure exerted by the therapeutic administration of colistin, could be responsible for the development of colistin resistance in our strain, as recently reported in E. aerogenes from France. Due to effective infection control measures, the colistin resistant strain did not spread to other patients or hospital wards. This is the first report of an ESBL-producing, colistin-resistant E. aerogenes in clinically relevant samples such as endotracheal aspirate and blood culture, showing the presence of this rare resistance profile among Gram-negative bacteria.

Enterobacter aerogenes ; colistin ; resistance

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Podaci o izdanju

30 (2)

2018.

120-123

objavljeno

1120-009X

1973-9478

10.1080/1120009X.2017.1382121

Povezanost rada

Temeljne medicinske znanosti

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