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Application of NMR Methods in Supramolecular Chemistry and Molecular Self-assemblies

Self-assembly of small organic molecules is one of the most important methods of synthesis of organic nano-structured materials. Based on the rules of supramolecular chemistry, the bottom- up approach to design functional objects at nanoscale is currently producing highly sophisticated materials oriented towards a growing number of applications. These structuring features are nowadays well understood and can be finely controlled in order to introduce and tune functional properties of self-assembled nanomaterials used for a very wide range of applications. Further, such systems exhibit a complex array of morphologies and dynamics and have a huge potential for utilization in various areas of nanotechnology, in development of new materials, diagnostic or "smart" systems for drug delivery, in medicine or in tissue engineering.[1, 2] In recent years, various chiral bis (amino acid) oxamides and other structural types that include amino acid subunits have been investigated as low molecular weight gelators with a particular focus on stereochemical effects and solvent influence on gel systems. [3–5] The molecular self-assembling and supramolecular interactions in the new supramolecular systems were studied by various spectroscopic methods e.g. NMR, FTIR, CD, that proved the self-aggregation of molecules. The contribution made by using of various NMR methods in the characterization of such systems will be shown through several examples.

NMR ; Self-assembly ; Supramolecular gels

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