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Pregled bibliografske jedinice broj: 945582

Časopis

Autori: Ašić, Adna; Marjanović, Damir; Mirat, Jure; Primorac Dragan
Naslov: Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives
Izvornik: Personalized medicine (1741-0541) 15 (2018), 3;
Vrsta rada: pregledni rad
Ključne riječi: anticoagulation ; apixaban ; dabigatran ; edoxaban ; novel oral anticoagulants ; pharmacogenetics ; rivaroxaban
Sažetak:
Novel oral anticoagulants (NOACs) are becoming a therapy of choice in everyday clinical practice after almost 50 years during which warfarin and related coumarin derivatives were used as the main anticoagulants. Advantages of NOACs over standard anticoagulants include their predictable pharmacodynamics and pharmacokinetics, stable plasma concentrations and less drug–drug and food–drug interactions. However, pharmacogenetics has its place in administration of NOACs, as considerable interindividual variations have been detected. In this review, previous findings in pharmacogenetics of dabigatran, rivaroxaban, apixaban and edoxaban are summarized, along with recommendations for studying genes encoding metabolically important enzymes for four selected NOACs. Future directions include identification of clinically relevant SNPs, and change in optimum dosage for patients who are carriers of significant variants.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Puni text rada: 945582.personalized_medicine_Asic_et_al.pdf (tekst priložen 2. Srp. 2018. u 09:10 sati)
URL Internet adrese: https://www.futuremedicine.com/doi/10.2217/pme-2017-0092
https://www.futuremedicine.com/doi/10.2217/pme-2017-0092
Broj citata:
Altmetric:
DOI: 10.2217/pme-2017-0092
URL cjelovitog teksta:
Google Scholar: Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives
Upisao u CROSBI: Damir Marjanović (damir.marjanovic@inantro.hr), 2. Srp. 2018. u 09:10 sati



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