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Pregled bibliografske jedinice broj: 946524

Časopis

Autori: Tomin, Marko; Tomić, Antonija; Kovačević, Borislav; Tomić, Sanja
Naslov: The Mechanism of Peptide Hydrolysis Catalysed by Dipeptidyl Peptidase III from Bacteroides thetaiotaomicron
( The Mechanism of Peptide Hydrolysis Catalysed by Dipeptidyl Peptidase III from Bacteroides thetaiotaomicron )
Izvornik: Croatica chemica acta (0011-1643) 91 (2018), 2; 187-193
Vrsta rada: članak
Ključne riječi: dipeptidyl peptidase III ; DPP III ; peptide hydrolysis ; reaction mechanism ; Bacteroides thetaiotaomicron
( dipeptidyl peptidase III ; DPP III ; peptide hydrolysis ; reaction mechanism ; Bacteroides thetaiotaomicron )
Sažetak:
Dipeptidyl peptidase III (DPP III) is a zinc- dependent peptidase that cleaves dipeptides off of N-termini of its substrates. Previous studies on human DPP III reveal a reaction mechanism similar to that of thermolysin. Since the active site is conserved within the DPP III family, it is not surprising that the mechanism determined for Bacteroides thetaiotaomicron DPP III (BtDPP III) closely resembles that of hDPP III. However, the hydrogen bond network within the model differs slightly from that in the human ortholog, which results in two proposed pathways. The calculated Gibbs activation energy of 90.1 kJ mol–1 is larger than the one calculated from kinetic data for the preferred substrate Arg2-2-naphthylamide at room temperature (69 kJ mol–1), suggesting the importance of treating the whole DPP III enzyme in the calculations.
Projekt / tema: HRZZ-IP-2013-11-7235
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL Internet adrese: http://fulir.irb.hr/4114/
https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=296070
Broj citata:
Altmetric:
DOI: 10.5562/cca3343
URL cjelovitog teksta:
Google Scholar: The Mechanism of Peptide Hydrolysis Catalysed by Dipeptidyl Peptidase III from Bacteroides thetaiotaomicron
Upisao u CROSBI: Antonija Tomić (Antonija.Tomic@irb.hr), 6. Srp. 2018. u 08:08 sati



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