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Pregled bibliografske jedinice broj: 949210

Časopis

Autori: Ključević, Nikola; Milat, Ana Marija; Grga, Mia; Mudnić, Ivana; Boban, Mladen; Grković, Ivica
Naslov: White Wine Consumption Influences Inflammatory Phase of Repair After Myocardial Infarction in Rats
( White Wine Consumption Influences Inflammatory Phase of Repair After Myocardial Infarction in Rats )
Izvornik: Journal of cardiovascular pharmacology (0160-2446) 70 (2017), 5; 293-299
Vrsta rada: članak
Ključne riječi: myocardial infarction, white wine, MMP-2, MMP-9, NF-kB, TGF-b
( myocardial infarction, white wine, MMP-2, MMP-9, NF-kB, TGF-b )
Sažetak:
Effects of white wine (WW) consumption on the expression of inflammatory markers/mediators (MMP-2, MMP-9, NF-ĸB p65 and TGF-b1) in myocardial tissue after experimentally induced permanent myocardial ischemia was investigated. Male Sprague-Dawley rats were given either a combination of WW and water or only water, for 28 days. After coronary ligation, animals were left to survive for 24 hours. Three representative areas: infarct/ ischemic, peri- infarct/border zone, and control/non-ischemic zones were analyzed for expression of immunoreactivity by measuring the threshold area % of signal density. For MMP-9, significantly smaller expression was found in all 3 zones of wine drinking animals (P<0.001). There was no difference in MMP-2 immunoreactivity between the 2 groups, except in peri-infarct zones, where the signal was significantly decreased (P<0.001). The same pattern of expression was found for the NF-kB p65 signal, although no differences between experimental groups were observed for TGF-b1. White wine consumption decreases the expression of the 3 investigated inflammatory markers/mediators in the peri- infarct zone, suggesting its significant modulatory effect. For MMP-9 and MMP-2, expression was similar to the effect of postischemic reperfusion. No effect on TGF-b1 was observed, highlighting its role in being the masterswitch, changing from the inflammatory to the proliferative stage of infarct healing.
Projekt / tema: Croatian Science Foundation Project no. 8652
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Interdisciplinarne prirodne znanosti,Temeljne medicinske znanosti,Kliničke medicinske znanosti,Nutricionizam,Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
URL Internet adrese: https://journals.lww.com/cardiovascularpharm/fulltext/2017/11000/White_Wine_Consumption_Influences_Inflammatory.4.aspx
Broj citata:
Altmetric:
DOI: 10.1097/fjc.0000000000000519
URL cjelovitog teksta:
Google Scholar: White Wine Consumption Influences Inflammatory Phase of Repair After Myocardial Infarction in Rats
Upisao u CROSBI: Ana Marija Milat (ana.marija.milat@mefst.hr), 25. Srp. 2018. u 10:06 sati



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