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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 951613

Časopis

Autori: Sabol, Maja; Trnski, Diana; Musani, Vesna; Ozretić, Petar; Levanat, Sonja
Naslov: Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets
( Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets )
Izvornik: International journal of molecular sciences (1422-0067) 19 (2018), 9;
Vrsta rada: pregledni rad
Ključne riječi: HH-GLI signaling pathway ; GLI transcription factors ; signal transduction ; malformations ; cancer ; therapy
( HH-GLI signaling pathway ; GLI transcription factors ; signal transduction ; malformations ; cancer ; therapy )
Sažetak:
GLI transcription factors have important roles in intracellular signaling cascade, acting as the main mediators of the HH-GLI signaling pathway. This is one of the major developmental pathways, regulated both canonically and non-canonically. Deregulation of the pathway during development leads to a number of developmental malformations, depending on the deregulated pathway component. The HH-GLI pathway is mostly inactive in the adult organism but retains its function in stem cells. Aberrant activation in adult cells leads to carcinogenesis through overactivation of several tightly regulated cellular processes such as proliferation, angiogenesis, EMT. Targeting GLI transcription factors has recently become a major focus of potential therapeutic protocols.
Projekt / tema: Grad Zagreb URBROJ: 251-03-02-15-2, HRZZ-IP-2016-06-1268
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Puni text rada: 951613.ijms-19-02562.pdf (tekst priložen 29. Kol. 2018. u 08:22 sati)
URL Internet adrese: http://www.mdpi.com/1422-0067/19/9/2562
http://fulir.irb.hr/4165/
http://www.mdpi.com/1422-0067/19/9/2562/pdf
Broj citata:
Altmetric:
DOI: 10.3390/ijms19092562
URL cjelovitog teksta:
Google Scholar: Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets
Upisao u CROSBI: Petar Ozretić (Petar.Ozretic@irb.hr), 29. Kol. 2018. u 08:22 sati



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