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Pregled bibliografske jedinice broj: 957077

Zbornik radova

Autori: Kukolj, Marina; Oršolić, Nada; Odeh, Dyana; Orct, Tatjana; Šimić, Goran; Horvat Langer, Lea; Šoštarić, Branko; Branović Čakanić, Karmen; Grabarević, Dunja; Terzić, Svjetlana
Naslov: EFFECTS OF ALUMINUM CHLORIDE ON LIPID PEROXIDATION AND DISTRIBUTION OF TOXIC AND ESSENTIAL/TRACE ELEMENTS IN RATS LIVER AND SPLEEN TISSUES
Izvornik: 13th CROATIAN BIOLOGICAL CONGRESS with International Participation / Kružić, Petar ; Caput Mihalić, Katarina ; Gottstein, Sanja ; Pavoković, Dubravko ; Kučinić, Mladen (ur.). -
Skup: 13th CROATIAN BIOLOGICAL CONGRESS with International Participation
Mjesto i datum: Poreč, Hrvatska, 19.-29.09.2018.
Ključne riječi: aluminum chloride, toxic elements, essential elements, detoxification
Sažetak:
Aluminum (Al) is a nonessential, toxic element which is assoiated with number of disorders in people (e.g. Alzheimer's disease). While, hematopoietic organs (liver and spleen) are the vital sites involved in detoxification. This study was aimed to explore antioxidative and detoxifying capacity of the liver and spleen after administration of aluminum chloride. Twelve male Y59 rats were intraperitoneally administered with: (a) 0, 9% NaCl (control group) and (b) AlCl3 (10 mg/kg) and D-(+)- galactose (60 mg/kg) per day consecutively for 28 days. The analysis of essential and toxic elements in the liver and spleen tissues was performed by mass spectrometry inductively coupled plasma (ICP-MS). Lipid peroxidation (LP) was measured by thiobarbituric acid assay in homogenates of liver and spleen. The results showed statistically significant increase of toxic metals (Al, Cd, As) in liver and spleen tissues, also essential/trace elements in liver (Co, Sr, Mo P, S, Ca, Fe, Cu, Zn, Se, Na, Mg) and spleen (Mo, Ca, Fe, Se) tissues of rats treated with AlCl3 compared to the control group. While P, S, Mn, Zn, Mg in the spleen was significantly reduced. The level of LP was significantly increased in spleen tissues of AlCl3-treated rats. The results indicate that AlCl3 interfere with the metabolic function of the liver and leads to disruption of trace element, while spleen has less changes in the essential elements but higher sensibility to proxidative effect of AlCl3.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: HRZZ-IP-2014-09-9730, 20282313
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Kemijsko inženjerstvo,Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
URL Internet adrese: http://www.hbd-sbc.hr/wordpress/wp-content/uploads/2018/09/13-HBKongres-Knjiga-sazetaka-13-CBC-Book-of-abstracts-2018.pdf
Upisao u CROSBI: Marina Kukolj (kukoljmarina@gmail.com), 26. Ruj. 2018. u 17:21 sati



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