crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 963979

Časopis

Autori: Crnogorac, Matija; Horvatić, Ivica; Kačinari, Patricia; Galešić Ljubanović, Danica; Galešić, Krešimir
Naslov: Serum C3 complement levels in ANCA associated vasculitis at diagnosis is a predictor of patient and renal outcome.
( Serum C3 complement levels in ANCA associated vasculitis at diagnosis is a predictor of patient and renal outcome. )
Izvornik: JN. Journal of nephrology (1121-8428) 31 (2018), 2; 257-262
Vrsta rada: članak
Ključne riječi: ANCA ; Anti myeloperoxidase autoantibodies ; Anti proteinase-3 autoantibodies ; C3 factor ; Complement ; Prognostic factors ; Vasculitis
( ANCA ; Anti myeloperoxidase autoantibodies ; Anti proteinase-3 autoantibodies ; C3 factor ; Complement ; Prognostic factors ; Vasculitis )
Sažetak:
AIM: To determinate the prognostic significance of low serum C3 at the time of diagnosis of ANCA- associated vasculitis (AAV). METHODS: Our cohort included 75 consecutive patients with AAV diagnosed from January 2005 to December 2015. C3 levels were measured at the time of diagnosis. Patients were divided into two groups, those with low serum C3 levels (< 0.9 g/l) and those with normal serum C3 levels (0.9-1.8 g/l). We analysed association between serum C3 levels and both combined and singularly patient and renal survival (ESRD). Small number of relapsed patients did not allow for the statistical analysis to be performed as to weather the low serum C3 is associated with relapse rate in AAV patients. RESULTS: Low serum C3 levels were significantly associated with worse combined end-point patient and renal survival (HR 3.079 ; 95% CI 1.231-7.701 ; p = 0.016), and on multivariate adjusted analysis association remained significant (HR 2.831 ; 95% CI 1.093-7.338 ; p = 0.032). For both end- points individually low serum C3 levels were significantly associated with poorer patient survival (HR 6.378 ; 95% CI 2.252-18.065 ; p < 0.001 ; on multivariate adjusted analysis HR 4.315 95% CI 1.350-13.799 ; p = 0.014) and renal survival (HR 3.207 ; 95% CI 1.040-9.830 ; p = 0.043 ; on multivariate adjusted analysis HR 3.679 ; 95% CI 1.144- 11.827 ; p = 0.029). In our study there was no significant association between serological and patohistological phenotypes and serum C3 levels. CONCLUSION: Lower serum C3 levels at the diagnosis is associated with poorer patient and renal outcomes in AAV patients.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Stručni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: https://link.springer.com/article/10.1007%2Fs40620-017-0445-3
Broj citata:
Altmetric:
DOI: 10.1007/s40620-017-0445-3
URL cjelovitog teksta:
Google Scholar: Serum C3 complement levels in ANCA associated vasculitis at diagnosis is a predictor of patient and renal outcome.
Upisao u CROSBI: Miroslav Tišljar (miroslav.tisljar@student.mef.hr), 26. Lis. 2018. u 13:26 sati



  Verzija za printanje   za tiskati


upomoc
foot_4