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Pregled bibliografske jedinice broj: 964238

Časopis

Autori: Pačić, Arijana; Šenjug, Petar; Bacalja, Jasna; Tišljar, Miroslav; Horvatić, Ivica; Bulimbašić, Stela; Knotek, Mladen; Galešić, Kršimir; Galešić Ljubanović, Danica
Naslov: IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis
( IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis )
Izvornik: Croatian medical journal (0353-9504) 58 (2017), 4; 281-291
Vrsta rada: članak
Ključne riječi: disease progresion, focal segmental glomerulosclerosis, IgM
( disease progresion, focal segmental glomerulosclerosis, IgM )
Sažetak:
AIM: To determine the role of immunoglobulin M (IgM) deposits in clinical manifestations, disease outcome, and treatment response of idiopathic and secondary focal segmental glomerulosclerosis (FSGS). METHODS: Kidney biopsy specimens of 171 patients diagnosed with FSGS (primary and secondary) and 50 control patients were retrospectively included in the study. For each patient, clinical and outcome data were obtained and compared to morphological parameters, including immunofluorescence analysis of mesangial IgM and complement 3 (C3) deposits analyzed on kidney biopsy samples. RESULTS: There were significant positive correlations between IgM and C3 deposition in secondary FSGS (P<0.001) and between IgM and mesangial deposits detected by electron microscopy in secondary FSGS (P=0.015), which indicated that higher IgM deposition correlated with higher C3 deposition and mesangial deposits only in secondary FSGS. Patients with secondary FSGS and the deposition of IgM showed inferior renal outcomes at earlier time points in comparison with patients with negative IgM expression (P=0.022). CONCLUSIONS: We detected a positive correlation between IgM and C3 in secondary FSGS. The association between IgM deposition and worse renal outcome in secondary FSGS indicates that IgM may play a role in the progression of this disease.
Projekt / tema: 198-0000000-3355
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: NE
Google Scholar: IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis
Upisao u CROSBI: Miroslav Tišljar (mtisljar@kbd.hr), 28. Lis. 2018. u 21:13 sati



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