Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis (CROSBI ID 255897)

Prilog u časopisu | izvorni znanstveni rad | domaća recenzija

Pačić, Arijana ; Šenjug, Petar ; Bacalja, Jasna ; Tišljar, Miroslav ; Horvatić, Ivica ; Bulimbašić, Stela ; Knotek, Mladen ; Galešić, Kršimir ; Galešić Ljubanović, Danica IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis // Croatian medical journal, 58 (2017), 4; 281-291

Podaci o odgovornosti

Pačić, Arijana ; Šenjug, Petar ; Bacalja, Jasna ; Tišljar, Miroslav ; Horvatić, Ivica ; Bulimbašić, Stela ; Knotek, Mladen ; Galešić, Kršimir ; Galešić Ljubanović, Danica

engleski

IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis

AIM: To determine the role of immunoglobulin M (IgM) deposits in clinical manifestations, disease outcome, and treatment response of idiopathic and secondary focal segmental glomerulosclerosis (FSGS). METHODS: Kidney biopsy specimens of 171 patients diagnosed with FSGS (primary and secondary) and 50 control patients were retrospectively included in the study. For each patient, clinical and outcome data were obtained and compared to morphological parameters, including immunofluorescence analysis of mesangial IgM and complement 3 (C3) deposits analyzed on kidney biopsy samples. RESULTS: There were significant positive correlations between IgM and C3 deposition in secondary FSGS (P<0.001) and between IgM and mesangial deposits detected by electron microscopy in secondary FSGS (P=0.015), which indicated that higher IgM deposition correlated with higher C3 deposition and mesangial deposits only in secondary FSGS. Patients with secondary FSGS and the deposition of IgM showed inferior renal outcomes at earlier time points in comparison with patients with negative IgM expression (P=0.022). CONCLUSIONS: We detected a positive correlation between IgM and C3 in secondary FSGS. The association between IgM deposition and worse renal outcome in secondary FSGS indicates that IgM may play a role in the progression of this disease.

disease progresion, focal segmental glomerulosclerosis, IgM

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

58 (4)

2017.

281-291

objavljeno

0353-9504

1332-8166

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost