ARTERIAL STIFFNESS AS MEASURE OF CARDIOVASCULAR RISK IN LEAN AND OBESE ADOLESCENTS AND ADOLESCENTS WITH TYPE 1 DIABETES (CROSBI ID 668417)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Putarek, Krešimir ; Banfić, Ljiljana ; Pašalić, Marijan ; Krnić, Nevena ; Špehar Uroić, Anita ; Rojnić Putarek, Nataša
engleski
ARTERIAL STIFFNESS AS MEASURE OF CARDIOVASCULAR RISK IN LEAN AND OBESE ADOLESCENTS AND ADOLESCENTS WITH TYPE 1 DIABETES
Objectives: Cardiovascular disease (CVD), the major cause of death worldwide, is the end result of vascular aging and atherosclerosis, having its origins in childhood. Pediatric patients harboring classical CVD risk include obese and diabetic patients. Noninvasive methods used to evaluate vascular function include intima-media thickness (IMT) and arterial stiffness (AS) assessed with pulse wave velocity (PWV), arterial compliance (AC) and β-stiffness measurements. Methods: We analyzed parameters of AS in 68 obese adolescents (13.27 ± 2.31 yrs), 42 adolescents with type 1 diabetes (T1D) (14.95 ± 2.35 yrs) with T1D duration over 5 years and 38 controls (15.02 ± 1.94 yrs). AS was assessed using e-tracking ultrasound method (EchoTracking®, Aloka alfa-10). Height, weight, body mass index (BMI) and blood pressure (BP) were assessed in all patients. Lipid levels were measured in obese and T1D patients, while oral glucose-tolerance test (OGTT), insulin level and HOMA index were assessed in obese patients. Results: Significant difference in AS between groups was found for AC (P=0, 022) and PWS (p=0.000) with the lowest compliance and higher velocities found in T1D group. The IMT measurements did not show significant difference between groups. Multiple regression analysis in obese adolescents showed correlation of lower AC in females (p=0.041) and in patients with higher systolic BP SDS (p=0, 032). In adolescents with T1D, duration of the disease was strongest independent determinant of AS for all measures (AC, β and PWV: p=0.028 ; p=0.029 and p=0.003, respectively) followed by BMI SDS which correlated with PWV and β-index (p=0.008 and p=0.033, respectively), and HbA1c that correlated with PWV (p=0.048). Both systolic and diastolic BP correlated with lower AC (SBP SDS p<0, 001 ; DBP SDS p=0, 049) and higher PWV (SBP SDS p=0, 023, DBP SDS p=0, 048). Conclusions: Even though obese adolescents have significantly higher body weight and BMI, lower HDL cholesterol and higher BP, early vascular damage was more pronounced in adolescents with T1D. This finding may reveal the influence of hyperglycemia and its consequences on blood vessels as a major risk for cardiovascular health.
aretrial stifness, cardiovascular risk, children, type 1 diabetes, obesity
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Podaci o prilogu
P3-1826
2017.
nije evidentirano
objavljeno
10.1159/000481423
Podaci o matičnoj publikaciji
Hormone Research in Paediatrics
Allen, David B
S. Karger
978-3-318-06237-3
1663-2818
1663-2826
Podaci o skupu
10th Joint Meeting of Pediatric Endocrinology
poster
14.09.2017-17.09.2017
Washington D.C., Sjedinjene Američke Države
Povezanost rada
Kliničke medicinske znanosti