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Arterial stiffness as a measure of cardiovascular risk in obese adolescents and adolescents with diabetes type 1 (CROSBI ID 257696)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Putarek, Krešimir ; Banfić, Ljiljana ; Pašalić, Marijan ; Krnić, Nevena ; Špehar Uroić, Anita ; Rojnić Putarek, Nataša Arterial stiffness as a measure of cardiovascular risk in obese adolescents and adolescents with diabetes type 1 // Journal of pediatric endocrinology & metabolism, 31 (2018), 12; 1315-1323. doi: 10.1515/jpem-2018-0137

Podaci o odgovornosti

Putarek, Krešimir ; Banfić, Ljiljana ; Pašalić, Marijan ; Krnić, Nevena ; Špehar Uroić, Anita ; Rojnić Putarek, Nataša

engleski

Arterial stiffness as a measure of cardiovascular risk in obese adolescents and adolescents with diabetes type 1

Background: Cardiovascular disease (CVD) is the end result of vascular aging and atherosclerosis, having its origins in childhood. The aim of our study was to compare arterial stiffness (AS) and intima-media thickness (IMT) as markers of an early vascular damage between obese adolescents, adolescents with diabetes type 1 (T1D) and lean control subjects. Methods: We analyzed AS and IMT in 68 obese adolescents (13.27 ± 2.31 years), 42 adolescents with T1D (14.95 ± 2.35 years) lasting over 5 years and 38 controls (15.02 ± 1.94 years). AS (measured by pulse wave velocity [PWV], arterial compliance [AC] and β-stiffness) and IMT were assessed using an e-tracking ultrasound method. Results: A significant difference between the groups was found for AC (p = 0.022) and PWV (p = 0.010), with the lowest compliance and higher velocities in T1D patients. When corrected for age, the difference in AC among the groups did not reach a statistical difference (p = 0.059). Correlation analysis in the obese adolescents showed lower AC in females (p = 0.041), with higher systolic blood pressure (SBP) (p = 0.032). In T1D adolescents, disease duration was the strongest determinant of AS (AC p = 0.028, β p = 0.029 and PWV p = 0.003), followed by body mass index (BMI ; PWV p = 0.008 ; β p = 0.033), SBP (AC p < 0.001 ; PWV p = 0.023), diastolic BP (AC p = 0.049 ; PWV p = 0.048) and HbA1c (PWV p = 0.048). No significant correlations were found for AS measures or IMT with sex, age, BMI, Tanner stage or BP levels in controls. Conclusions: Early vascular damage is more pronounced in T1D adolescents than in obese or lean adolescents, which may emphasize the impact of hyperglycemia as a major threat for cardiovascular health.

adolescents ; arterial stiffness ; cardiovascular risk ; diabetes type 1 ; obesity.

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nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

31 (12)

2018.

1315-1323

objavljeno

0334-018X

2191-0251

10.1515/jpem-2018-0137

Povezanost rada

Kliničke medicinske znanosti

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