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Pregled bibliografske jedinice broj: 973977

Časopis

Autori: Kekin, Ivana; Bošnjak, Dina; Makarić, Porin; Bajić, Žarko; Rossini Gajšak, Linda; Malojčić, Branko; Boban, Marina; Rojnić Kuzman, Martina
Naslov: Significantly lower right middle cerebral artery blood flow velocity in the first episode of psychosis during neurocognitive testing.
( Significantly lower right middle cerebral artery blood flow velocity in the first episode of psychosis during neurocognitive testing. )
Izvornik: Psychiatria Danubina (0353-5053) 30 (2018), 2; 172-182
Vrsta rada: članak
Ključne riječi: Intracranial blood flow ; First psychotic episode ; Neurocognitive test ; Neuroimaging ; Schizophrenia
( Intracranial blood flow ; First psychotic episode ; Neurocognitive test ; Neuroimaging ; Schizophrenia )
Sažetak:
BACKGROUND: Changes in cerebral hemodynamics have been reported in schizophrenia and proposed as underlying the cognitive deficits seen in patients. The objective of our study was to compare changes of the cerebral blood flow velocity (BFV) during neurocognitive tasks between the patients with the first episode of psychosis and healthy controls. SUBJECTS AND METHODS: We recruited 46 patients with the first episode of psychosis (FEP), admitted to the University Hospital Centre Zagreb during 2016-2017 and 41 control subjects. Transcranial Doppler ultrasonography monitoring of BFV in both middle cerebral arteries was recorded during 25-minute long neurocognitive assessment with Phonemic Verbal Fluency test, Trial Making Test B and Stroop test. Between every consecutive test resting periods were recorded. RESULTS: After the adjustment for age, sex and education by quantile regression, patients with FEP had significantly lower BFV in middle cerebral arteries during the 3rd (Δ-15, Δ%-28% p=0.023) and 4th task (Δ-15, Δ%-28% p=0.031) of the Stroop test and the 1st task of Foot tapping test (Δ -16, Δ% -30% p=0.034). We observed significantly lower changes of right middle cerebral artery BFV in FEP between two consecutive tests in all four tasks of the Phonemic verbal fluency test, 1st and 2nd task of the Stroop test and Trail making test, and the1st task of Foot tapping test ; and of the left artery between first three tasks of the Phonemic verbal fluency test, the last one of the Phonemic verbal fluency test and all first three tasks of the Stroop test. CONCLUSIONS: Decreased middle BFV during the execution of particular neurocognitive tasks in patients with FEP, compared to control subjects might indicate impaired hemodynamic function in the prefrontal/parietal brain areas, and possibly provide an explanation of some of the observed neurocognitive deficits in patients with the first episode of psychosis.
Projekt / tema: HRZZ-UIP-2014-09-1245
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Broj citata:
Altmetric:
DOI: 10.24869/psyd.2018.172
URL cjelovitog teksta:
Google Scholar: Significantly lower right middle cerebral artery blood flow velocity in the first episode of psychosis during neurocognitive testing.
Upisao u CROSBI: Dina Bošnjak (dina.bosnjak@mefst.hr), 13. Pro. 2018. u 17:49 sati



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