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Pregled bibliografske jedinice broj: 980630

Časopis

Autori: Trbojević-Akmačić, Irena; Vučković, Frano; Vilaj, Marija; Skelin, Andrea; Karssen, Lennart C.; Krištić, Jasminka; Jurić, Julija; Momčilović, Ana; Šimunović, Jelena; Mangino, Massimo; De Gregori, Manuela; Marchesini, Maurizio; Dagostino, Concetta; Štambuk, Jerko; Novokmet, Mislav; Rauck, Richard; Aulchenko, Yurii S.; Primorac, Dragan; Kapural, Leonardo; Buyse, Klaas; Mesotten, Dieter; Williams, Frances M.K.; van Zundert, Jan; Allegri, Massimo; Lauc, Gordan
Naslov: Plasma N-glycome composition associates with chronic low back pain
Izvornik: Biochimica et Biophysica Acta (BBA) - General Subjects (0304-4165) 1862 (2018), 10; 2124-2133
Vrsta rada: članak
Ključne riječi: Glycan biomarker ; Low back pain ; Plasma N-glycosylation ; Retrospective study
Sažetak:
BACKGROUND: Low back pain (LBP) is the symptom of a group of syndromes with heterogeneous underlying mechanisms and molecular pathologies, making treatment selection and patient prognosis very challenging. Moreover, symptoms and prognosis of LBP are influenced by age, gender, occupation, habits, and psychological factors. LBP may be characterized by an underlying inflammatory process. Previous studies indicated a connection between inflammatory response and total plasma N-glycosylation. We wanted to identify potential changes in total plasma N-glycosylation pattern connected with chronic low back pain (CLBP), which could give an insight into the pathogenic mechanisms of the disease. METHODS: Plasma samples of 1128 CLBP patients and 760 healthy controls were collected in clinical centers in Italy, Belgium and Croatia and used for N-glycosylation profiling by hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC) after N-glycans release, fluorescent labeling and clean-up. Observed N-glycosylation profiles have been compared with a cohort of 126 patients with acute inflammation that underwent abdominal surgery. RESULTS: We have found a statistically significant increase in the relative amount of high-branched (tri-antennary and tetra-antennary) N-glycan structures on CLBP patients' plasma glycoproteins compared to healthy controls. Furthermore, relative amounts of disialylated and trisialylated glycan structures were increased, while high-mannose and glycans containing bisecting N-acetylglucosamine decreased in CLBP. CONCLUSIONS: Observed changes in CLBP on the plasma N-glycome level are consistent with N-glycosylation changes usually seen in chronic inflammation. GENERAL SIGNIFICANCE: To our knowledge, this is a first large clinical study on CLBP patients and plasma N-glycome providing a new glycomics perspective on potential disease pathology.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Broj citata:
Altmetric:
DOI: 10.1016/j.bbagen.2018.07.003
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: NE
Google Scholar: Plasma N-glycome composition associates with chronic low back pain
Upisao u CROSBI: Jelena Šimunović (jsimunovic@student.pharma.hr), 21. Sij. 2019. u 12:28 sati



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