crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 985956

Časopis

Autori: Sikirić, Predrag; Ručman, Rudolf; Turković, Branko; Sever, Marko; Kliček, Robert; Radić, Božo; Drmić, Ivan Domagoj; Stupnišek, Mirjana; Mišić, Marija; Batelja Vuletić, Lovorka; Horvat Pavlov, Katarina; Barišić, Ivan; Kokot, Antonio; Peklić, Marina; Strbe, Sanja; Boban Blagaić, Alenka; Tvrdeić, Ante; Stančić-Rokotov, Dinko; Vrčić, Hrvoje; Starešinić, Mario; Seiwerth, Sven
Naslov: Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing
( Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing )
Izvornik: Current pharmaceutical design (1381-6128) 24 (2018), 18; 1990-2001
Vrsta rada: članak
Ključne riječi: Stable gastric pentadecapeptide BPC 157 ; control of blood vessels function ; cytoprotection ; endothelium protection ; organoprotection ; stomach cells protection
( Stable gastric pentadecapeptide BPC 157 ; control of blood vessels function ; cytoprotection ; endothelium protection ; organoprotection ; stomach cells protection )
Sažetak:
Years ago, we revealed a novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157, particular anti- ulcer peptide that heals different organs lesions when given as a therapy, native in human gastric juice while maintaining GI-tract mucosal integrity, already tested in trials (ulcerative colitis and now multiple sclerosis). The stomach cytoprotection is the most fundamental concept, stomach cell protection and endothelium protection are largely elaborated, but so far cell, protection and endothelium protection outside of the stomach were not implemented in the therapy. However, having managed these two points, stomach cell protection and endothelium protection, either one or together, even much more than standard cytoprotective agents do, BPC 157 employed large scale of its beneficial effects seen in various organs. Providing endothelium protection, BPC 157 was shown to prevent formation and reverse established thrombosis in anastomosed abdominal aorta as well as venous thrombosis after inferior caval vein occlusion, and attenuate bleeding prolongation and thrombocytopenia after amputation, without or with anticoagulants, or venous occlusion, and finally counteract effect of L-NAME and/or L-arginine. Now, with BPC 157 application, we reveal the third most important part of the cytoprotection concept: with the stomach cell and endothelium protection to recover mucosal integrity, BPC 157 as prototype cytoprotective agent should also control blood vessel function, depending upon injury, perforated defect or vessel obstruction. After a perforated injury (i.e., stomach), BPC 157 therapy activates blood vessels "running" towards defect. After obstruction (i.e., inferior caval vein), BPC 157 activates vessels "running" towards bypassing defect, collaterals functioning. Reestablished blood flow, and largely reversed injurious course may practically implement the cytoprotection concept.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.eurekaselect.com/162924/article
Broj citata:
Altmetric:
DOI: 10.2174/1381612824666180608101119
URL cjelovitog teksta:
Google Scholar: Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing
Upisao u CROSBI: Marija Mišić (mmisic@vef.hr), 20. Vel. 2019. u 23:56 sati
Napomene:
Rad/casopois je indeksiran i u TOC Premier i Ulrich's Periodicals Directory.



  Verzija za printanje   za tiskati


upomoc
foot_4