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Pregled bibliografske jedinice broj: 989470

Časopis

Autori: Josic, D; Martinović, Tamara; Pavelić, Krešimir
Naslov: Glycosylation and metastases
Izvornik: Electrophoresis (0173-0835) 40 (2019), 1; 140-150
Vrsta rada: članak
Ključne riječi: Alternation ; Biomarker candidates ; Glycosylation ; Malignant transformation ; Tumor metastasis
Sažetak:
The change of cellular glycosylation is one of the key events in malignant transformation and neoplastic progression, and tumor-related glycosylation alterations are promising targets in both tumor diagnosis and therapy. Both malignant transformation and neoplastic progression are the consequence of gene expression alterations and alterations in protein expression. Micro environmental factors such as extracellular matrix (ECM) also play an important role in their growth and metastasis. Tumor-associated glycans are important biomarker candidates for cancer diagnosis and prognosis, and analytical methods for their detection were developed recently. Glycoproteomics that use mass spectrometry for identification of cancer antigens and structural analysis of glycans play a key role in the investigation of changes of glycosylation during malignant transformation and tumor development and metastasis. Deep understanding of glycan remodeling in cancer and the role of glycosyltransferases that are involved in this process will require a detailed profiling of glycosylation patterns of tumor cells, and corresponding analytical methods for their detection were developed.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
URL Internet adrese: https://www.ncbi.nlm.nih.gov/pubmed/30246896
Broj citata:
Altmetric:
DOI: 10.1002/elps.201800238
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: NE
Google Scholar: Glycosylation and metastases
Upisao u CROSBI: Lara Saftić (lara.saftic@student.uniri.hr), 13. Ožu. 2019. u 11:51 sati



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