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Pregled bibliografske jedinice broj: 989794

Časopis

Autori: Poljak, LJiljana; Verstovšek S; Knežević, Nikola; Užarević, Branka; Batinić, Drago; Pavelić, Krešimir; Marušić-Galešić, Suzana
Naslov: Cyclosporine A differently affects the function of the two Main T cell subsets
Izvornik: Croatian medical journal (0353-9504) 33 (1992); 102-106
Vrsta rada: članak
Ključne riječi: Cyclosporine A, T-cell subsets, immunosuppression, IL-2 production, CD4+, CD8+
Sažetak:
Cyclosporine A (CysA) is a potent immunosuppressive agent, widely used for prevention of graft rejection in organ transplantation. It exerts immunosuppressive effect in vivo primarily due to its influence on the function of T cells. At which point exactly CysA affects T cell function is still unknown. In the present study we have investigated the effect of Cys A on the T cell proliferation and IL-2 production by CD4+ -enriched and CD8+ -enriched T cells, isolated from the spleen of normal mice. We found that the proliferation of CD8+ T cells was much more sensitive on the Cys A presence than CD4+ T cell proliferation. On the other hand, IL-2 production by CD4+ T cells was more affected by the Cys A presence than IL-2 production by CD8+ T cells. We suggest that there are at least two different models of Cys A action – one affecting IL-2 production and the other affecting T cell proliferation.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: NE
Google Scholar: Cyclosporine A differently affects the function of the two Main T cell subsets
Upisao u CROSBI: Lara Saftić (lara.saftic@student.uniri.hr), 14. Ožu. 2019. u 13:46 sati



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