engleski

Stature Is Related to Renal Impairment and Higher Pulse Pressure Only in Women

Background: It was reported that short adult stature might be a risk factor for premature cardiovascular diseses.However, data on association of height and kidney function are sparse. Our aim was to analyze this association in general population with normal kidney function. Methods: In this cross-sectional survey conducted in general population from continental area out of original cohort of 2412 subjects, 644 subjects (324 W ; 320 M) (age 40, 35-43) with eGFR MDRD>60ml/min/1.73m2 and ACR<30mg/g were enrolled.Blood pressure (BP) was measured according to the ESH/ESC guidelines.Men and women were separately divided into height quartiles (Q1 the lowest and Q4 the highest height). Results: There were no differences in age and BMI between height Qs in both gender. Women in the tallest height Qs were more obese (p<0.001), had lower eGFR(79±10 versus 85±12, p=0.005) and lower pulse pressure (PP) (42±12 versus 48±13, p=0.032) compared to those in shortest height Q.There were no differences in BP, ACR and alpha1CR between height Qs.On univariate regression height was associated with eGFR (B=-0.34, SE=0.10 ; p=0.001) and ACR (B=0.13, SE=0.05 ; p=0.008).The association remained signifi cant after adjustment for age, PP, BMI, ACR and alpha1CR for eGFR (B=- 0.61, SE=0.13 ; p<0.001) and ACR (B=0.17, SE=0.06 ; p=0.008).There were no differences in eGFR, ACR and BP values between height Qs in men.On univariate regression we failed to fi nd association of height with eGFR and ACR in men. Conclusions: In the group of subjects without CKD, short stature is related to lower eGFR, higher ACR and higher pulse pressure only in women.Additionally, PP adjusted adult stature was related to renal impairment only in women.Further investigations are needed to confi rm our fi ndings and analyze whether higher PP could be related to the early renal impairment in subjects with taller stature. Funding: Government Support - Non-U.S.

Stature, Pulse pressure, gender, Kidney function

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