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Pregled bibliografske jedinice broj: 715114

Časopis

Autori: Jurak, Igor; Brune, Wolfram
Naslov: Induction of apoptosis limits cytomegalovirus cross-species
Izvornik: EMBO journal (0261-4189) 25 (2006), 11; 2634-2642
Vrsta rada: članak
Ključne riječi: apoptosis; caspase; cytomegalovirus; species specificity; vMIA
Sažetak:
Cross-species infections are responsible for the majority of emerging and re-emerging viral diseases. However, little is known about the mechanisms that restrict viruses to a certain host species, and the factors viruses need to cross the species barrier and replicate in a different host. Cytomegaloviruses (CMVs) are representatives of the beta-herpesviruses that are highly species specific. They replicate only in cells of their own or a closely related species. In this study, the molecular mechanism underlying the cytomegalovirus species specificity was investigated. We show that infection of human cells with the murine cytomegalovirus (MCMV) triggers the intrinsic apoptosis pathway involving caspase-9 activation. MCMV can break the species barrier and replicate in human cells if apoptosis is blocked by Bcl-2 or a functionally analogous protein. A single gene of the human cytomegalovirus encoding a mitochondrial inhibitor of apoptosis is sufficient to allow MCMV replication in human cells. Moreover, the same principle facilitates replication of the rat cytomegalovirus in human cells. Thus, induction of apoptosis serves as an innate immune defense to inhibit cross-species infections of rodent CMVs.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija
URL Internet adrese: http://onlinelibrary.wiley.com/doi/10.1038/sj.emboj.7601133/abstract
Broj citata:
Altmetric:
DOI: 10.1038/sj.emboj.7601133
URL cjelovitog teksta:
Google Scholar: Induction of apoptosis limits cytomegalovirus cross-species
Upisao u CROSBI: Igor Jurak (igor.jurak@biotech.uniri.hr), 15. Ruj. 2014. u 12:48 sati



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