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Pregled bibliografske jedinice broj: 154985

Zbornik radova

Autori: Kraljević, Sandra; Štambuk, Nikola; Kralj, Marijeta; Konjevoda, Paško
Naslov: Met-enkephalin and naloxone effects on head and neck squamous cell carcinoma cell lines
Izvornik: Book of Abstracts MATH/CHEM/COMP 2004 / Graovac, Ante ; Pokrić, Biserka ; Smrečki, Vilko (ur.). - Zagreb : Institut , 2004. 36-36.
Skup: MATH/CHEM/COMP 2004 - The 19th Dubrovnik International Course & Conference on the Interfaces among Mathematics, Chemistry and Computer Sciences
Mjesto i datum: Dubrovnik, Hrvatska, 21.-26.06.2004.
Ključne riječi: head; met-enkephalin; naloxone; neck; squamous cell carcinoma
Sažetak:
Met-enkephalin is a neuropeptide with multifunctional properties on cell growth, division and differentiation. Its effects include in vitro and in vivo modulation of tumor cell growth via delta and/or zeta opioid receptors. We investigated the effects of met-enkephalin and naloxone (opioid receptor antagonist) on cell lines CAL-27 and Detroit-562 of the head and neck squamous cell carcinoma (HNSCC). The influence of met-enkephalin and naloxone on tumor cell lines growth was evaluated using MTT cell proliferation assay. Tested substances were applied in the range of pharmacologically relevant concentrations (10-6 to 10-3 M). Dose-response curve analysis of met-enkephalin and naloxone effects on the tumor cell growth was done by means of GraphPad Prism Software, version 4.0. We found that opioid receptor blockade was the primary mechanism of agents' negative influence on CAL-27 and Detroit-562 cell line growth.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 0098092, 0098097
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti



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