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Pregled bibliografske jedinice broj: 251134

Zbornik radova

Autori: Bratulić, Siniša; Jurišić, Davor; Bujak, M.; Karminski-Zamola, Grace; Žinić, Biserka; Pavelić, Krešimir; Kraljević Sandra
Naslov: Biološki učinci tri novopripravljena spoja na stanične kulture dobivene iz pacijenata oboljelih od Dupuytrenove kontrakture
Izvornik:
Skup: EMBO/HHMI Central European Scientists Meeting
Mjesto i datum: Cavtat, Hrvatska, 15.6.-17.6.2006.
Ključne riječi: Dupuytrenova kontraktura; terapija; primarna stanična kultura
Sažetak:
Dupuytren's contracture (DC) is a palmar fibromatosis with partially elucidated aetiology. It is characterized by nodular fibroblastic proliferation and accumulation of myofibroblasts giving rise to the permanent contracture of the palm. So far, the only successful treatment was surgical excision or incision of diseased fascia, often accompanied by high recurrence rates. Experimental chemotherapy, such as 5-fluorouracil (5-FU) proved to be useful in acting locally in the palm by inhibiting myofibroblasts proliferation. 5-FU was shown to inhibit both, proliferation and myofibroblast differentiation in DC's cell cultures. We have therefore established primary cell cultures as a model for studying the effects of three newly synthesized chemical compounds on proliferation and differentiation of Dupuytren's fibroblasts/myofibrobalsts. Cells were characterized by proliferation assays, immunocytochemistry and the cell cycle analysis. We have tested cytotoxic and antiproliferatve effects of an N-sulfonylpyrimidine derivative, an amidino substituted benzimidazo(1, 2-a)quinoline derivative and an amido-substituted dithieno-kinolone derivative by MTT-test.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 0125005, 0098093
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti



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