crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 456038

Zbornik radova

Autori: Sedić, Mirela; Cindrić, Mario; Peronja, Marija; Ćuk, Mario; Barić Ivo; Vučinić, Srđan; Kraljević Pavelić, Sandra
Naslov: Proteomic analysis of plasma from infants with S-adenosylhomocysteine hydrolase deficiency
Izvornik: 3rd Summer Course on Mass Spectrometry in Biotechnology and Medicine, DubrovnikDubrovnik :
Skup: 3rd Summer Course on Mass Spectrometry in Biotechnology and Medicine
Mjesto i datum: Dubrovnik, Hrvatska, 28.06.-02.07.2009.
Ključne riječi: S-adenosylhomocysteine hydrolase (SAHH); methylation; Proteomic study
Sažetak:
Human S-adenosylhomocysteine hydrolase (SAHH) deficiency is a rare inherited disorder of obscure pathogenesis characterized primarily by delayed psychomotor development, marked hypotonia and abnormally slow myelination. Major biochemical hallmarks of the disease include low concentrations of plasma phosphatidylcholine and free choline, significantly increased creatine kinase and aminotransferases, as well as specific amino acid aberrations, e.g. dramatically elevated plasma S-adenosylhomocysteine, S-adenosylmethionine and methionine levels. In an attempt to contribute to better understanding of the molecular processes underlying this disease, we adopted a proteomic approach to analyze plasma samples derived from 3 Croatian infants aged 5 and 2 years and 3 months diagnosed with SAHH deficiency versus their age-matched controls. For that purpose, plasma proteins depleted of albumin and IgG were resolved by two-dimensional gel electrophoresis, and differentially expressed protein spots were identified by the means of MALDI-TOF mass spectrometry. Obtained results pointed to up- and down-regulation of 8 and 5 proteins, respectively in SAHH deficiency, which are engaged in diverse biological processes including lipid transport and metabolism, signal transduction, immune response, protein ubiquitination, vitamin transport and cell growth and division.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108-1081870-1885, 335-0000000-3532
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: kjuras@mef.hr (kjuras@mef.hr), 30. Ožu. 2010. u 12:57 sati



Verzija za printanje   za tiskati


upomoc
foot_4