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Pregled bibliografske jedinice broj: 480507

Zbornik radova

Autori: Peternel, Sandra; Manestar-Blažić, Teo; Ćelić, Tanja; Prpić-Massari, Larisa; Brajac, Ines; Kaštelan, Marija
Naslov: Expression of tumour necrosis factor-like weak inducer of apoptosis in normal human skin, inflammatory dermatoses and non-melanoma skin cancer
Izvornik: Journal of Investigative Dermatology, 2010 ; 130 (Suppl 2s)Nature Publishing Group , 2010. S54.
ISSN: 0022-202X
Skup: 40th Annual Meeting of the European Society for Dermatological Research
Mjesto i datum: Helsinki, Finska, 08-11.09.2010.
Ključne riječi: TWEAK; psoriasis; lichen planus; skin cancer
Sažetak:
Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily of cytokines that possesses a variety of biological effects including stimulation of cell growth and angiogenesis, tissue regeneration, induction of proinflammatory cytokines and stimulation of apoptosis. To investigate the role of TWEAK in skin biology, we performed immunofluorescent analyses of TWEAK expression in normal human skin, psoriasis, lichen planus, actinic keratosis (AK), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). In normal epidermis, strong positive cytoplasmic staining for TWEAK was observed in all keratinocyte layers except the basal cell layer which was entirely unstained. Similar pattern of staining was found in psoriasis with clearly observable difference between unstained basal and occasional suprabasal cells and strongly stained upper layers of epidermis. This "clear cut" difference in the staining pattern was not observed in lesions of lichen planus, where the overall staining intensity was decreased but occasional positively stained nuclei were also detected. Decreased staining was additionally observed in AK, particularly in the areas of cellular atypia. In SCC, strong signal was seen in the well-differentiated keratinocytes around squamous pearls whereas poorly differentiated cells showed weak or absent signal. In BCC, TWEAK was almost completely absent, with only a few individual cells in a limited number of BCCs positively stained. In conclusion, these data suggest that TWEAK is associated with keratinocyte differentiation in normal skin, inflammatory dermatoses and non-melanoma skin cancer and that it is possibly involved in the apoptotic keratinocyte death in lichen planus.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 062-0620239-0199, 062-0620239-0197
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.nature.com/jid/journal/v130/n2s/index.html
http://www.nature.com/jid/journal/v130/n2s/pdf/jid2010238a.pdf
Upisao u CROSBI: peternel@medri.hr (peternel@medri.hr), 8. Ruj. 2010. u 21:45 sati



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