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Pregled bibliografske jedinice broj: 549684

Časopis

Autori: Markić, Dean; Ćelić, Tanja; Gršković, Antun; Španjol, Josip; Fučkar, Željko; Grahovac, Blaženka; Đorđević, Gordana; Bobinac, Dragica
Naslov: mRNA expression of bone morphogenetic proteins and their receptors in human renal cell carcinoma
Izvornik: Urologia internationalis (0042-1138) 87 (2011), 3; 353-358
Vrsta rada: članak
Ključne riječi: bone morphogenetic protein; renal cell carcinoma; kidney
Sažetak:
Bone morphogenetic proteins (BMPs) have been studied in several cancers, but only limited information is available about renal cell carcinomas (RCCs). We determined the expression of mRNA of several BMP ligands and BMP receptors (BMPRs) in healthy kidney tissue and RCCs, and data were compared to clinicopathological parameters. Sixty-four samples of RCCs and healthy renal tissues were prospectively examined. The expression of BMP2, BMP4, BMP6, BMP7, BMPRIA, BMPRIB and BMPRII mRNA was determined using semiquantitative reverse transcriptase-polymerase chain reaction. The expression levels of different BMP ligands and BMPRs were considerably higher in RCCs than in normal kidney tissue. BMP ligands showed elevated expression in clear-cell RCCs, whereas all three BMPRs showed higher expression levels in non- clear-cell RCCs. In clear-cell RCCs, the expression levels of BMP2 progressively increased and expression levels of BMP6, BMP7 and BMPRIB were lost with higher tumor stage. All BMPs and their receptors have stronger expression levels in RCC. The expression level of BMP2 is strongly elevated in kidney cancer.
Projekt / tema: 062-0620226-0207
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.karger.com/Article/FullText/330797
Broj citata:
Altmetric:
DOI: 10.1159/000330797
URL cjelovitog teksta:
Google Scholar: mRNA expression of bone morphogenetic proteins and their receptors in human renal cell carcinoma
Upisao u CROSBI: dragica@medri.hr (dragica@medri.hr), 22. Stu. 2011. u 10:32 sati



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