crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 552856

Časopis

Autori: Marić, Ivana; Kučić, Natalia; Turk, Tamara; Smoljan, Ivana; Grahovac, Blaženka; Zoričić Cvek, Sanja; Ćelić, Tanja; Bobinac, Dragica; Vukičević, Slobodan
Naslov: BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy
Izvornik: American journal of physiology-gastrointestinal and liver physiology (0193-1857) 302 (2012), 10; G1151-G1162
Vrsta rada: članak
Ključne riječi: BMPs; TNBS colitis; Inflammatory bowel disease; Smad proteins
Sažetak:
Beyond stimulating bone formation, the bone morphogenetic proteins (BMPs) are important in development, inflammation and malignancy of the gut. We have previously shown that BMP7 has a regenerative, anti-inflammatory and anti- proliferative effect on experimental inflammatory bowel disease (IBD) in rat. To further investigate the BMP signaling pathway we monitored the effect of BMP7 therapy on the BMP signaling components in rat colon during different stages of experimentally induced colitis by 2, 4, 6- trinitrobenzene sulfonic acid (TNBS). The results showed increased of BMP2 and -7 expression in the chronic phase of colitis. BMP7 treatment slightly enhanced BMP4, -6 and -7, and suppressed the BMP2 expression. CTGF and noggin expression was elevated in TNBS colitis, and slightly decreased upon BMP7 therapy. BMP receptor I expression was unchanged, while BMP receptor II was increased at day 14 and 30 of TNBS inflammation, and decreased following BMP7 therapy. BMP7 increased Smad1, Smad3 and Smad4. Inhibitory Smads were increased in colitis, but not in rats treated with BMP7. We conclude that BMP signaling is preserved in colon during TNBS-induced colonic inflammation and could be modulated with BMP7, suggesting that IBD is a reversible process with self-recovery features.
Projekt / tema: 062-0620226-0209, 062-0000000-3540, 062-0620226-0207, 062-0620226-0208, 062-0000000-3550, 062-0000000-3559, 108-1080327-0320
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://ajpgi.physiology.org/content/302/10/G1151.abstract
Broj citata:
Altmetric:
DOI: 10.1152/ajpgi.00244.2011
URL cjelovitog teksta:
Google Scholar: BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy
Upisao u CROSBI: ivanam@medri.hr (ivanam@medri.hr), 23. Stu. 2011. u 13:45 sati



  Verzija za printanje   za tiskati


upomoc
foot_4