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Pregled bibliografske jedinice broj: 579505

Časopis

Autori: Domitrović, Robert; Cvijanović, Olga; Pernjak Pugel, Ester; Blagojević Zagorac, Gordana; Mahmutefendić, Hana; Škoda, Marko
Naslov: Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney
( Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney )
Izvornik: Toxicology (0300-483X) 310 (2013); 115-123
Vrsta rada: članak
Ključne riječi: cisplatin nephrotoxicity; luteolin; oxidative/nitrosative stress; inflammation; apoptosis
( cisplatin nephrotoxicity; luteolin; oxidative/nitrosative stress; inflammation; apoptosis )
Sažetak:
The aim of this study was to investigate the effects of flavone luteolin against cisplatin (CP)-induced kidney injury in mice. Luteolin at doses of 10mg/kg was administered intraperitoneally (ip) once daily for 3 days following single CP (10 or 20mg/kg) ip injection. Mice were sacrificed 24h after the last dose of luteolin. The CP treatment significantly increased serum creatinine and blood urea nitrogen and induced pathohistological changes in the kidneys. Renal oxidative/nitrosative stress was evidenced by decreased glutathione (GSH) levels and increased 3-nitrotyrosine (3-NT) and 4- hydroxynonenal (4-HNE) formation as well as cytochrome P450 2E1 (CYP2E1) expression. The CP administration triggered inflammatory response in mice kidneys through activation of nuclear factor- kappaB (NF-κB) and overexpression of tumor necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2). Simultaneously, the increase in renal p53 and caspase-3 expression indicated apoptosis of tubular cells. The administration of luteolin significantly reduced histological and biochemical changes induced by CP, decreased platinum (Pt) levels and suppressed oxidative/nitrosative stress, inflammation and apoptosis in the kidneys. These results suggest that luteolin is an effective nephroprotective agent, with potential to reduce Pt accumulation in the kidneys and ameliorate CP-induced nephrotoxicity.
Projekt / tema: 062-0000000-3554, 062-0621261-1269, Sveučilište u Rijeci, potpora 13.06.1.2.24
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Farmacija
URL Internet adrese: http://ac.els-cdn.com/S0300483X13001534/1-s2.0-S0300483X13001534-main.pdf?_tid=94db77d6-f214-11e3-913a-00000aacb362&acdnat=1402565776_e4f5ad6c926701aca6f7e6cbd969150c
http://www.sciencedirect.com/science/article/pii/S0300483X13001534
Broj citata:
Altmetric:
DOI: 10.1016/j.tox.2013.05.015
URL cjelovitog teksta:
Google Scholar: Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney
Upisao u CROSBI: robertd@medri.hr (robertd@medri.hr), 9. Svi. 2012. u 17:35 sati



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