crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 652237

Časopis

Autori: Španjol, Josip; Ćelić, Tanja; Markić, Dean; Đorđević, Gordana; Marić, Ivana; Fučkar, Željko; Rački, Sanjin; Bobinac, Dragica
Naslov: Expression of receptor activator of nuclear factor-kappa B ligand in leukocytes during acute kidney rejection after transplantation in rats
Izvornik: Transplantation proceedings (0041-1345) 45 (2013), 5; 1766-1770
Vrsta rada: članak
Ključne riječi: RANKL; RANK; kidney transplantation; T cells; macrophages
Sažetak:
Acute cellular rejection of the transplanted kidney is an important cause of impaired graft function. One of the basic characteristics of acute cellular rejection according to the latest Banff classification of renal allograft pathology is the presence of a large number of T lymphocytes in the allografted tissue. Osteoprotegerin, receptor activator of nuclear factor-kappa B (RANK) and RANK ligand (RANKL), three relatively novel members of the tumor necrosis factor superfamily, have crucial roles not only in physiologic and pathologic bone metabolism but also in immunologic processes. The aim of our study was to determine the expression of RANKL and RANK by T lymphocytes and macrophages in acute cellular kidney allograft rejection in rats. The study included 15 male Wistar rats of 3 months old and 250-300 g as recipients and 15 male DA rats donors of 3 months old ; and weight 250-300 g. When animals were sacrificed at 3 weeks to extract the transplanted kidney for pathohistologic analysis and immunoflorescence. all samples showed acute cellular rejection. Kidney sections were examined by dual-labeled immunofluorescence to detect CD4, CD8, or CD68 (red) and RANK or RANKL (green) with coexpressing cells as orange. RANKL-positive expression colocalized with CD4(+) and CD8(+) T lymphocytes in acutely rejected kidney tissue. There was no association between CD4(+) and CD8(+) T cells with RANK expression, which was evident by infiltrating CD68-positive macrophages in the kidney tissue interstitium. RANK and RANKL were expressed by T lymphocytes and macrophages in acute cellular kidney rejection after transplantation in rats.
Projekt / tema: 062-0620226-0209, 062-0620226-0207
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0041134512014261
http://ac.els-cdn.com/S0041134512014261/1-s2.0-S0041134512014261-main.pdf?_tid=4c012304-8205-11e4-a904-00000aacb361&acdnat=1418392179_0c6eca2b3c199331c677e04180797c01
Broj citata:
Altmetric:
DOI: 10.1016/j.transproceed.2012.10.065
URL cjelovitog teksta:
Google Scholar: Expression of receptor activator of nuclear factor-kappa B ligand in leukocytes during acute kidney rejection after transplantation in rats
Upisao u CROSBI: Ivana Marić (ivana.maric@uniri.hr), 6. Stu. 2013. u 11:55 sati
Napomene:
Rad je prezentiran na skupu The 24th International Congress of the Transplantation Society.



  Verzija za printanje   za tiskati


upomoc
foot_4