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Pregled bibliografske jedinice broj: 702641

Časopis

Autori: Mikolašević, Ivana; Rački, Sanjin; Zaputović, Luka; Lukenda, Vesna; Sladoje-Martinović, Branka; Orlić, Lidija
Naslov: Nonalcoholic fatty liver disease (NAFLD) and cardiovascular risk in renal transplant recipients
( Nonalcoholic fatty liver disease (NAFLD) and cardiovascular risk in renal transplant recipients )
Izvornik: Kidney & blood pressure research (1420-4096) 39 (2014), 4; 308-314
Vrsta rada: članak
Ključne riječi: cardiovascular disease; renal transplant recipients; nonalcoholic fatty liver disease (NAFLD); transient elastography
( cardiovascular disease; renal transplant recipients; nonalcoholic fatty liver disease (NAFLD); transient elastography )
Sažetak:
Renal transplant recipients (RTRs) are at high risk for cardiovascular (CVD) mortality. Recently, nonalcoholic fatty liver disease (NAFLD) has been recognized as a new risk factor for adverse CVD events in the general population. We examined whether transient elastography (TE) defined NAFLD was associated with atherosclerosis in RTRs, as measured by ultrasound in the carotid arteries. Carotid atherosclerosis was assesses in 71 RTRs with a TE proven NAFLD. With the help of TE liver stiffness was used to assess liver fibrosis and Controlled Attenuation Parameter (CAP) was used to detect and quantify liver steatosis. NAFLD was defined by the presence of steatosis with CAP values ≥238 dB.m-1. RTRs with NAFLD showed more carotid atherosclerosis than RTRs without NAFLD. RTRs-NAFLD patients had the mean intima-media measurements (ITM) of 1.1±0.1 mm and that was statistically significant higher than the mean ITM founded in RTRs without NAFLD (1.1±0.1 vs. 0.9±0.1 mm ; p<0.0001). Furthermore, RTRs-NAFLD patients had statistically significant higher prevalence of plaques in comparison with RTRs without NAFLD (p=0.021). We showed for the first time that carotid atherosclerosis is advanced in RTRs with NAFLD. Detection of NAFLD by TE should alert to the existence of an increased cardiovascular risk in RTRs.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: https://www.karger.com/Article/FullText/355808
Broj citata:
Altmetric:
DOI: 10.1159/000355808
URL cjelovitog teksta:
Google Scholar: Nonalcoholic fatty liver disease (NAFLD) and cardiovascular risk in renal transplant recipients
Upisao u CROSBI: Sanjin Rački (sanjin.racki@uniri.hr), 28. Lip. 2014. u 04:26 sati



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