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Pregled bibliografske jedinice broj: 715171

Časopis

Autori: Jurak, Igor; Griffiths, A.; Coen, D.M.
Naslov: Mammalian alphaherpesvirus miRNAs
Izvornik: Biochimica Biophysica Acta. Gene Regulatory Mechanisms (1874-9399) 1809 (2011), 11/12; 641-653
Vrsta rada: članak
Ključne riječi: miRNA; herpesvirus
Sažetak:
Mammalian alphaherpesviruses are major causes of human and veterinary disease. During productive infection, these viruses exhibit complex and robust patterns of gene expression. These viruses also form latent infections in neurons of sensory ganglia in which productive cycle gene expression is highly repressed. Both modes of infection provide advantageous opportunities for regulation by microRNAs. Thus far, published data regarding microRNAs are available for six mammalian alphaherpesviruses. No microRNAs have yet been detected from varicella zoster virus. The five other viruses-herpes simplex viruses-1 and -2, herpes B virus, bovine herpesvirus-1, and pseudorabies virus-representing both genera of mammalian alphaherpesviruses have been shown to express microRNAs. In this article, we discuss these microRNAs in terms of where they are encoded in the viral genome relative to other viral transcripts ; whether they are expressed during productive or latent infection ; their potential targets ; what little is known about their actual targets and functions during viral infection ; and what little is known about the interactions of these viruses with the host microRNA machinery. This article is part of a Special Issue entitled: "MicroRNAs in viral gene regulation".
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S1874939911001027
URL cjelovitog teksta:
Google Scholar: Mammalian alphaherpesvirus miRNAs
Upisao u CROSBI: Igor Jurak (igor.jurak@biotech.uniri.hr), 15. Ruj. 2014. u 14:48 sati



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