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Pregled bibliografske jedinice broj: 715185

Časopis

Autori: Kramer, M.F.; Jurak, Igor; Pesola, J.M.; Boissel, S.; Knipe, D.M.; Coen, D.M.
Naslov: Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia
Izvornik: Virology (0042-6822) 417 (2011), 2; 239-247
Vrsta rada: prethodno priopćenje
Ključne riječi: miRNA latency; Herpes simplex virus; microRNAs; latency; gene regulation
Sažetak:
Several herpes simplex virus 1 microRNAs are encoded within or near the latency associated transcript (LAT) locus, and are expressed abundantly during latency. Some of these microRNAs can repress the expression of important viral proteins and are hypothesized to play important roles in establishing and/or maintaining latent infections. We found that in lytically infected cells and in acutely infected mouse ganglia, expression of LAT-encoded microRNAs was weak and unaffected by a deletion that includes the LAT promoter. In mouse ganglia latently infected with wild type virus, the microRNAs accumulated to high levels, but deletions of the LAT promoter markedly reduced expression of LAT-encoded microRNAs and also miR-H6, which is encoded upstream of LAT and can repress expression of ICP4. Because these LAT deletion mutants establish and maintain latent infections, these microRNAs are not essential for latency, at least in mouse trigeminal ganglia, but may help promote it.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0042682211002911
Broj citata:
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DOI: 10.1016/j.virol.2011.06.027
URL cjelovitog teksta:
Google Scholar: Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia
Upisao u CROSBI: Igor Jurak (igor.jurak@biotech.uniri.hr), 15. Ruj. 2014. u 15:00 sati



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