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Pregled bibliografske jedinice broj: 737033

Zbornik radova

Autori: Jurišić, Davor; Kraljević Pavelić, Sandra; Dević Pavlić, Sanja; Markova-Car, Elitza
Naslov: Circadian gene polymorphisms in melanoma personalized medicine approach
Izvornik: 1st Euro-Asian Melanoma Congress : abstracts
Skup: Euro-Asian Melanoma Congress (1 ; 2014)
Mjesto i datum: Sarajevo, Bosnia-Herzegovina, 18.-21.09.2014.
Ključne riječi: melanoma; clock genes; snp; personalized medicine
Sažetak:
Circadian timing system transmits environmental signals to a core oscillator that generates circadian signals responsible for the peripheral physiological or behavioural events. It has been documented that impaired function of this intricate circadian system might be linked with diverse pathologic processes including cancer. Among all types of skin cancers the most aggressive form is melanoma and its link with deregulated circadian system has still not been studied in details. In particular, literature data point to altered expression of clock genes in human skin as an early event during malignant transformation of cells. A personalized medicine approach based on analysis of molecular alterations at the level of genome, proteome and metabolome might be therefore, helpful in assessing the status of the clock system axis, establishment of novel putative biomarkers and help in stratification of melanoma patients in accordance to disease phenotype and/or therapy outcome. Even though a small number of researches have been done in this area, the potential for improvement of melanoma management is huge and warrants future investigation efforts.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
Upisao u CROSBI: Elitza Petkova Markova Car (elitza@biotech.uniri.hr), 2. Pro. 2014. u 14:35 sati



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