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Pregled bibliografske jedinice broj: 745847

Zbornik radova

Autori: Ćelić, Tanja; Marić, Ivana; Markić, Dean; Španjol, Josip; Gršković, Antun; Bobinac, Dragica
Naslov: Modulators of osteogenic, inflammatory and apoptotic response in vascular calcification
Izvornik: 3rd International Congress of Croatian Association for Protection of non Ionizing Radiation : Abstract book
Skup: International Congress of Croatian Association for Protection of non Ionizing Radiation (3 ; 2009)
Mjesto i datum: Opatija, Hrvatska, 23.-25.10.2009.
Ključne riječi: bone morphogenetic proteins
Sažetak:
Vascular calcification is associated with older age, atherosclerosis, diabetes mellitus and chronic kidney disease. Recent studies show that bone formation proteins are involved in vascular calcification. This process is considered to be regulated similar as bone tissue mineralization. We demonstrated up regulation of bone morphogenetic protein-2 (BMP-2) and RANK ligand (RANKL) in calcified areas, both identified as favors of calcification. The inhibitor of calcification, osteoprotegerin (OPG) is present in non diseased arteries and decreased with calcification occurence. Our results also show increased expression of another postulated calcification inhibitor BMP-7 and osteopontin (OPN). OPN is negatively associated with decreasement of alfa SMA. Loss of alfa SMA is followed by osteogenic phenotype appearance in calcified vasculature.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Projekt / tema: 062-0620226-0207, 0062075
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
Upisao u CROSBI: Dean Markić (dean.markic@medri.uniri.hr), 6. Sij. 2015. u 18:57 sati



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