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Pregled bibliografske jedinice broj: 745852

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Autori: Markić, Dean; Španjol, Josip; Gršković, Antun; Ćelić, Tanja; Fučkar, Željko; Bobinac, Dragica
Naslov: Bone morphogenetic proteins in normal and carcinomatous kidney tissue
Izvornik: Abstract bookZagreb :
Skup: 8th Urological Alpe Adria Meeting
Mjesto i datum: Zagreb, Hrvatska, 02.10.2010.
Ključne riječi: bone morphogenetic proteins; kidney cancer
Sažetak:
Bone morphogenetic proteins (BMPs) are cytokines which are important for kidney homeostasis but also have role in the some renal diseases and renal cell carcinoma (RCC). In the last three decades incidence of RCC was constantly increased and the role of different molecular biomarkers in RCC is explored. We analysed expression of BMP-6, BMP-7, their receptors (BMPR-IA, BMPR-IB, BMPR-II) and proteins of their signaling pathway (pSmad1/5/8) in sixteen renal cancer samples and paired normal tissue. Tissue samples were analysed by immunohistochemistry and Western blot. BMP-7, BMP receptors and pSmad1/5/8 were expressed in all structures of normal kidney but dominantly in the proximal tubular cells. In the cancer samples their expression was also noticed. Expression of BMP-6 was not noticed in any tissue with immunohistochemistry. Comparison of BMPs between different tissue showed increased expression of BMPR-IB and pSmad 1/5/8 and decreased expression of BMP-6, BMP-7 and BMPR-II in RCC compared to normal kidney. BMPR-IA was detected with immunohistochemistry but with Western blot attenuated signal was presented. Detected alterations of BMP-6, BMP-7, BMP receptors and pSmad expression in RCC suggested their possible role in tumorigenesis of kidney cancer.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 0062075
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
Upisao u CROSBI: Dean Markić (dean.markic@medri.uniri.hr), 6. Sij. 2015. u 19:17 sati



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