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Pregled bibliografske jedinice broj: 825990

Zbornik radova

Autori: Meščić, Andrijana; Harej, Anja; Kraljević Pavelić, Sandra; Stepanić, Višnja; Raić-Malić, Silvana
Naslov: 1, 2, 3-Triazole appended L-ascorbic acid with antioxidant properties
Izvornik: 17th Tetrahedron Symposium Challenges in Biological, Bioorganic, Organic & Medicinal Chemistry
Skup: 17th Tetrahedron Symposium Challenges in Biological, Bioorganic, Organic & Medicinal Chemistry
Mjesto i datum: Sitges, Španjolska, 28.06.-01.07.2016.
Ključne riječi: L-askorbinska kiselina ; 1 ; 2 ; 3-triazol ; hvatač radikala ; antitumorski agens
Sažetak:
Since the discovery of vitamin C, the number of its known biological functions is continually expanding. Various pyrimidines and purines containing L-ascorbic acid exhibited significant antiproliferative effects against malignant human tumour cell lines.1 Vitamin C is a biologically significant reducing agent due to its 1-oxo-2- ene-2, 3-diol structural moiety. Furthermore, 1, 2, 3-triazoles have attracted considerable attention in recent years because of their wide range of biological activities against various viruses, malignant cells, microorganisms and their inhibitory activities against several enzymes.2 A series of 1, 4-substituted 1, 2, 3-triazole derivatives of L-ascorbic acid have been synthesized as potential antitumor compounds. The influence of the substituent R2 at the C-4 of the triazole ring on the radical scavenging capacity was also examined. Results of the biological evaluations of novel compounds will be presented.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: HRZZ-IP-2013-11-5596
Izvorni jezik: ENG
Kategorija: Ostalo
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Puni text rada: 825990.A.Mescic-Barcelona-TETRAH._Spdf (tekst priložen 7. Srp. 2016. u 16:33 sati)
Upisao u CROSBI: Andrijana Meščić (amescic@fkit.hr), 7. Srp. 2016. u 16:33 sati



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