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Pregled bibliografske jedinice broj: 843281

Zbornik radova

Autori: Stepanić, Višnja, Meščić, Andrijana; Harej, Anja; Kraljević Pavelić, Sandra; Raić-Malić, Silvana
Naslov: Design of novel hybrid compounds of vitamin C and 1, 2, 3-triazole with anticancer properties – impact of physicochemical profile on biological activity
Izvornik: The book of abstracts. HDIR-4: “From Bench to Clinic”. Fourth Meeting of the Croatian Association for Cancer Research with International Participation.Libri oncologici : Croatian journal of oncology. 44 (1) (2016) / Ozretić, Petar ; Levanat, Sonja (ur.). - Zagreb : University Hospital Center Sestre Milosrdnice, University Hospital for Tumors , 2016. 24.
ISSN: 0300-8142
Skup: HDIR-4: “From Bench to Clinic”. Fourth Meeting of the Croatian Association for Cancer Research with International Participation.
Mjesto i datum: Zagreb, Hrvatska, 3-4.11.2016.
Ključne riječi: vitamin C; 1; 2; 3-traizole; hybrids; antiproliferative; physico-chemical properties
Sažetak:
Vitamin C has been known as a reducing agent with a number of biological functions (Du et al., Biochim Biophys Acta 2012). On another side, compounds with a 1, 2, 3-triazole fragment have shown antiproliferative activities against a variety of cancer cell lines (Kraljević et al., Eur J Med Chem 2016). Design of a library of novel hybrid compounds of vitamin C and 1, 2, 3-triazole with various physicochemical characteristics (such as lipophilicity and solubility) and antioxidant capacity, through interdisciplinary approach will be outlined. The molecular properties have been modulated through introduction of various substituents at the C-4 atom of 1, 2, 3-triazole and their impact on biological activities has been estimated by using in silico modelling (Cruciani et al., J Mol Struct Theochem 2000), which will be presented.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: HRZZ-IP-2013-11-5596
Izvorni jezik: ENG
Kategorija: Ostalo
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
Upisao u CROSBI: Višnja Stepanić (Visnja.Stepanic@irb.hr), 8. Stu. 2016. u 11:42 sati



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