crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 916101

Zbornik radova

Autori: Tomić, Draško; Puškarić, Miroslav; Car, Zlatan
Naslov: In silico testing of the toxicity for some anticancer herbal compounds
Izvornik: Proceedings of International Conference on Innovative Technologies / Pepelnjak Tomaž ; Car Zlatan ; Kudláček Jan (ur.). - Jaromer, Czech Republic : Faculty of Engineering, University of Rijeka , 2017. 217-220.
ISSN: 0184-9069
Skup: IN-TECH 2017 International Conference on Innovative Technologies
Mjesto i datum: Ljubljana, Slovenija, 11-13.09.2017
Ključne riječi: anticancer herval compounds ; in silico testing of toxicity ; dose dependent level of toxicity ; successive cumulation of drug in tissues
Sažetak:
Herbal based anticancer drugs are known for their relative low toxicity compared to standard chemoterapeutics. Besides, the developing of cancer resistance to herbal based drug is less frequent, due to the complex drug structure. However, as each drug, these drugs can also express the considerable and in some cases even fatal dose dependent level of toxicity, when applied in to high doses. Another cause of toxicity can be a too long period of therapy, due to the successive cumulation of a drug in the tissues. Besides, the toxicity can be expressed as genotoxicity, cardiotoxicity, dermal toxicity, hepatotoxicity, nephrotoxicity and receptor- mediated toxicity, or any combination of them. Therefore, and especially in cases when standard chemoterapeutics are no choice, the application of herbal based anticancer drugs is the only choice. As clinical trials for these class of drugs are relative rare, their toxicity is mostly unknown. For this, we performed in silico testing for several herbal anticancer compounds, and where available, compared the results with toxicity data gathered from in vivo experiments. Our results show in silico testing of toxicity of anticancer herbal compounds is of the outmost importance in cased when the standard therapy fails, in vivo experimental data are missing or incomplete, and the quick alternative therapy is the only way to aleviate cancer related clinical simptoms.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Cjeloviti rad (više od 1500 riječi)
Vrsta recenzije: Međunarodna recenzija
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Računarstvo,Biotehnologija,Informacijske i komunikacijske znanosti
Upisao u CROSBI: Miroslav Puškarić (miroslav.puskaric@biotech.uniri.hr), 4. Sij. 2018. u 11:39 sati



Verzija za printanje   za tiskati


upomoc
foot_4