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Pregled bibliografske jedinice broj: 136161

Časopis

Autori: Bobinac, Dragica; Španjol, Josip; Zoričić, Sanja; Marić, Ivana
Naslov: Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans
( Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans )
Izvornik: Bone (New York, N.Y.) (8756-3282) 32 (2003), 3; 284-290
Vrsta rada: članak
Ključne riječi: osteoarthritis ; tibial plateau ; safranin-O staining ; cartilage degeneration ; subchondral bone ; histomorphometry
( osteoarthritis ; tibial plateau ; safranin-O staining ; cartilage degeneration ; subchondral bone ; histomorphometry )
Sažetak:
In this study, we have examiner the correlation between the histological and histochemical changes of articular cartilage and bone parameters of the underlying subchondral bone. The aim was to elucidate patterns of bone parameter changes within different depths of subchondral bone in the joints with macroscopically normal cartilage and in joints with osteoarthritis (OA). Ten tibial plateaus were taken from patients during total knee replacement surgery due to severe OA. They were compared with 10 sets of tibial condyles obtained from autopsy subjects with no history of bone or joint disease. The cylindrical cartilage-bone samples were taken out from the anterior, posterior, external, and internal areas of the condyles for cartilage assessment (Mankin score) and subchondral bone histomorphometry. Four histomorphometric parameters were measured: bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.S). Our study showed that subchondral bone from the OA group had significantly higher bone volume (54.1+/-10.6%) than control group (37.8+/-8.1%) (P<0.01). In addition, trabecular parameters from the OA subchondral bone showed a smaller number of sparsely distributed and thicker trabecules than in control group (P<0.05). Medial and lateral condyle from the control group did not differ significantly, with medial condyle from OA group showed a high increased of bone volume (62.8+/-13.3) and consecutively different trabecular parameters when compared with the lateral condyle from the same group. Also, it was shown that there are regional differences (anterior, posterior, internal, and external) in bone parameters between both condyles within both, control and OA groups. Comparison of bone parameters from three different stage of articular cartilagr degeneration (Mankin score) showed that higher degree of cartilage degeneration is followed by significant changes in subchondral bone architecture. Furthermore, we have found that progression of cartilage degeneration leads to changes in bone parameters which affected deeper levels of subchondral bone. According to these results, it can be suggested that chsnges in histomorphometric parameters of subchondral bone are secondary to cartilage damage and proceed deeper into subchondral bone with increasing cartilage degeneration.
Projekt / tema: 0062075
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S8756328202009821
Broj citata:
Altmetric:
DOI: 10.1016/S8756-3282(02)00982-1
URL cjelovitog teksta:
Google Scholar: Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans



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