crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 300373

Časopis

Autori: Pavelić, Jasminka; Radaković, Branko; Pavelić, Krešimir
Naslov: Insulin-like growth factor 2 and its receptors (IGF 1R and IGF 2R/mannose 6- phosphate) in endometrial adenocarcinoma
Izvornik: Gynecologic oncology (0090-8258) 105 (2007), 3; 727-735
Vrsta rada: članak
Ključne riječi: IGF proteins; endometrial adenocarcinoma; molecular targeted therapy
Sažetak:
To investigate the consequences of IGF proteins dysfunction in development of endometrial adenocarcinomas. The expression of IGF 2 and IGF 1R was correlated with the expression of IGF 2R and apoptosis rate in 59 human endometrial adenocarcinomas, 10 endometrial hyperplasias and 7 normal tissues. The presence of mutations in the IGF 2R gene was followed in 46 adenocarcinomas. We also examined the effect of IGF 1 receptor blockage on cancer cell proliferation. In groups of either IGF 2-positive or IGF 2-negative tumors (stages III and IV) the expression of IGF 1 and IGF 1R was correlated with cell proliferation index and telomerase activity. The expression of IGF 2 and IGF 1R was much higher in malignant tissue of stages III and IV than in tumors of stages I and II and normal or hyperplastic endometrium. This correlated with a decreased apoptosis rate and IGF 2R expression. Eight adenocarcinomas expressed biallelic mutation of the IGF 2R gene. The specific inhibition of IGF 1R and IGF 2 decreased tumor cell proliferation in IGF 2/IGF 1R-positive tumors. Furthermore, the positive correlation between increased expression of IGF 1 and IGF 1R proteins and increased telomerase activity and cell proliferation index was found in both IGF 2-negative and IGF 2-positive tumors. Our data suggest that IGF 1, IGF 2 and their receptors are involved in the progression of endometrial adenocarcinomas. As cancer cell proliferation can be abrogated by blocking mRNA or protein products of these genes, tumors with extensive involvement of the IGF 2 pathway would be candidates for the therapeutics strategies aimed at interference with this pathway.
Projekt / tema: 065-0982464-2532, 098-0982464-2394
Izvorni jezik: ENG
Rad je citiran u
bazama podataka:
Web of Science: Science Citation
Current Contents Citation Index
Scopus
Web of Science: Science Citation Index Expanded
MEDLINE
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Dentalna medicina
URL Internet adrese: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG6-4NCK25M-3&_user=3875467&_coverDate=06%2F30%2F2007&_rdoc=29&_fmt=full&_orig=browse&_srch=doc-info(%23toc%236814%232007%23998949996%23656147%23FLA%23display%23Volume)&_cdi=6814&_sort=d&_docanchor=&_ct=49&_acct=C000050661&_version=1&_urlVersion=0&_userid=3875467&md5=03b5f6fea8e4c164264005130b14e703
URL cjelovitog teksta:
Google Scholar: Insulin-like growth factor 2 and its receptors (IGF 1R and IGF 2R/mannose 6- phosphate) in endometrial adenocarcinoma
Upisao u CROSBI: Jasminka Pavelić (jpavelic@irb.hr), 21. Lip. 2007. u 13:53 sati



  Verzija za printanje   za tiskati


upomoc
foot_4