crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 314832

Zbornik radova

Autori: Bobinac, Dragica; Marić, Ivana; Markić, Dean; Cvijanović, Olga; Španjol, Josip; Ćelić, Tanja; Fučkar, Željko
Naslov: The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer
Izvornik: Abstracts of the 34th European Symposium on Calcified Tissues ; u: Calcified Tissue International (2007) (S) / Civitelli, Roberto (ur.). - New York : Springer , 2007. s61-s61.
ISSN: 0171-967X
Skup: European Symposium on Calcified Tissues (34 ; 2007)
Mjesto i datum: Kopenhagen, Danska, 05.-09.05.2007.
Ključne riječi: bone morphogenetic protein-7; BMP-receptors; kidney; kidney cancer; immunohistochemistry
Sažetak:
Bone morphogenetic protein-7 has an important role during fetal kidney development. In adult human kidney the expression was found in proximal tubule and glomerular podocytes. The function of BMP-7 in normal kidney is still unclear but the reviews revealed protective role of BMP-7 in acute and chronic kidney disease. BMP-7 is efficient as antifibrotic factor and is able to reverse epithelial-mesenchymal transformation. The aim of the study was to explore the expression of BMP-7 in human normal kidney and kidney cancer cells. Immunohistochemical staining with anti BMP-7, anti BMPR-IA, anti BMPR-IB and anti BMPR-II was performed. Slides were incubated with the primary antibodies overnight at 4°C in PBS. The expression of BMP-7 was found in epithelial cells of distal tubule. But the expression of related BMPs receptors was found in epithelial cells od fistal and proximal tubules. Among receptors BMPR-IB expression was very strong. In the tissue of kidney cancer the expression of BMP-7 was negative. In the borderline tissue of the kidney cancer the expression of BMP-7 was still present. In the kidney cancer cells the expression of BMPs receptors was present especially BMPR-IA and BMPR-IB while BMPR-II was less expressed.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 062-0620226-0209, 062-0620226-0208, 062-0620226-0207
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: Ivana Marić (Ivana.Maric@medri.hr), 17. Pro. 2007. u 16:03 sati



  Verzija za printanje   za tiskati


upomoc
foot_4