crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 343070

Časopis

Autori: Muačević-Katanec, Diana; Bradamante, Vlasta; Poljičanin, Tamara; Reiner, Željko; Babić, Zdravko; Simeon-Rudolf, Vera; Katanec, Davor
Naslov: Clinical study on the effect of simvastatin on paraoxonase activity
Izvornik: Arzneimittel-Forschung (0004-4172) 57 (2007), 10; 647-653
Vrsta rada: članak
Ključne riječi: paraoxonase 1 (PON1; aryldialkylphosphatase); low density lipoprotein (LDL) cholesterol; high density lipoprotein cholesterol; simvastatin
Sažetak:
Human paraoxonase (PON1) is a serum high-density lipoprotein-associated phosphotriesterase. High-density lipoprotein (HDL) plays the role of a carrier and the site of action of this enzyme. According to a majority of authors, PON1 acts as an antioxidant, preventing low-density lipoprotein (LDL) peroxidation. However, due to the fact that in vivo serum PON1 is predominantly associated with HDL, its major physiological role might be to protect HDL, rather than LDL, from oxidation. Nevertheless, the physiological substrate of PON1 still remains to be discovered. The objective of this study was to determine changes in PON1 activity during treatment with simvastatin (CAS 79902-63-9, Lipex) in patients with type IIa and/or IIb hyperlipoproteinemia. PON1 activity was assessed in 32 patients with hyperlipoproteinemia type IIa or IIb with an LDL cholesterol concentration higher than 4.2 mmol/l. Patients received simvastatin in a daily dose of 20 mg. The lipid status and PON1 activity were assessed at baseline, as well as 3 and 6 months after the beginning of treatment. The study demonstrated a statistically significant lipid lowering effect of simvastatin on total and LDL cholesterol, and an increase in PON1 activity in patients with both types of hyperlipoproteinemia. No statistically significant correlation was observed either between changes in PON1 activity and HDL, HDL2, HDL3 and LDL cholesterol and triglyceride levels, or between their first differences in patients with both type IIa and IIb hyperlipoproteinemia. The obtained results suggest that the antioxidant properties of simvastatin might be caused by a mechanism independent of apoAI-containing lipoprotein concentration. The antioxidant properties of simvastatin, which play an important role in HDL protection from oxidation, could be the mechanism inducing the increase in PON1 activity.
Projekt / tema: 065-0650446-0435, 108-1080134-0121, 108-0000000-0013
Izvorni jezik: ENG
Rad je citiran u
bazama podataka:
Web of Science: Science Citation
Current Contents Citation Index
MEDLINE
Scopus
Web of Science: Science Citation Index Expanded
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Dentalna medicina
URL cjelovitog teksta:
Google Scholar: Clinical study on the effect of simvastatin on paraoxonase activity
Upisao u CROSBI: vbradam@mef.hr (vbradam@mef.hr), 7. Svi. 2008. u 18:27 sati



  Verzija za printanje   za tiskati


upomoc
foot_4