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Pregled bibliografske jedinice broj: 379010

Zbornik radova

Autori: Župan, Gordana; Peternel, Sandra; Pilipović, Kristina; Blagaić, Ana; Hrelja, Ana; Vitezić, Dinko
Naslov: Effects of pioglitazone on the lipid peroxidation levels and COX-2 expressions in different brain structures of rats with lithium plus pilocarpine- induced status epilepticus
Izvornik: Abstracts of the 12th Congress of the European Federation of Neurological Societies ; u: European Journal of Neurology. Volume 15 (2008) (S3) / Lenzi, Gian Luigi ; Gil-Nagel, Antonio (ur.). - Madrid : Blackwell Publishing , 2008. 307-307.
ISSN: 1351-5101
Skup: Congress of the European Federation of Neurological Societies (12)
Mjesto i datum: Madrid, Španjolska, 23-26.08.2008.
Ključne riječi: status epilepticus; oxidative stress; cyclooxygenase-2; pioglitazone; rats
Sažetak:
In our previous study we demonstrated that pioglitazone, a synthetic agonist of the peroxisome proliferator-activated receptors (PPAR) gamma, causes the prominent increase of the 24 h- survival rate in rats with lithium plus pilocarpine-induced status epilepticus (SE), that provides a common experimental model of temporal lobe epilepsy (TLE) in humans. With the aim to investigate possible mechanisms underlying mentioned drug effect, we determined the lipid peroxidation levels and COX-2 expressions in some brain structures of rats with SE and treated by pioglitazone. Experiments were performed on 80 to 90 days old male Wistar rats. Pioglitazone (1 ; 3 mg/kg) or vehicle were administered i.p. 10 min after the lithium plus pilocarpine-induced SE, that was interrupted 2 h after its onset by an injection of diazepam. Rats were sacrificed 24 h after the SE onset and Western blotting analyses of COX-2 expressions were performed in the piriform/entorhinal cortex, temporal neocortex and in the hippocampus. Levels of the brain lipid peroxidation were determined by thiobarbituric acid reactive substances (TBARS) assay. Lithium plus pilocarpine-induced SE caused increases in the lipid peroxidation levels and COX-2 overexpressions in all examined brain regions. In rats with SE and treated by pioglitazone, TBARS levels were reduced in the piriform/entorhinal cortex and in the temporal neocortex. COX-2 overexpression was decreased in the hippocampus. Conclusion: Our results suggest that pioglitazone could be a candidate drug to protect examined brain structures in patients with TLE.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 062-0620529-0519
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www3.interscience.wiley.com/journal/121376924/issue
Upisao u CROSBI: kristina@medri.hr (kristina@medri.hr), 19. Sij. 2009. u 19:11 sati



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