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Pregled bibliografske jedinice broj: 385559


Autori: Balen, Sanja; Ružić, Alen; Mirat, Jure; Peršić, Viktor
Naslov: Exercise induced von Willebrand Factor release - New model for routine endothelial testing
( Exercise induced von Willebrand Factor release - New model for routine endothelial testing )
Izvornik: Medical hypotheses (0306-9877) 69 (2007), 6; 1320-1322
Vrsta rada: članak
Ključne riječi: endothelial dysfunction; von Willebrand factor; exercise testing
( endothelial dysfunction; von Willebrand factor; exercise testing )
Endothelial dysfunction (ED) is actively involved in the mechanism of occurrence, development and progression of all the degrees of atherosclerosis. The established impact of ED on the progress and outcome of cardiovascular diseases, together with convincing indications of a possible successful therapeutic modification, necessitate the changeover of ED assessment from experimental to a routine practice. As there is no appropriate method for a clinical practice, scientists anticipate significant research efforts in the further development. Among numerous methods already available, von Willebrand Factor (vWF) stands out significantly. In accordance with the accepted leading diagnostic role of vWF baseline levels in the group of peripheral endothelial markers, and earlier scientific observations on the absence of its expected reactivation during physical exercise, we hypothesised this promising theory. We believe that a constant stronger release of vWF in endothelial cell injury leads to the exhaustion of its stores in Weibel– Palade bodies with the consequent absence of the expected rise of concentration during the exercise. Therefore, we hypothesised that ED could be exhaustible vWF endothelopathy and the exercise induced release of vWF a new, simple, safe and reliable test for the detection of ED and monitoring of the expected therapeutic effect. In order to have a final clinical usability of the proposed diagnostic model, it is necessary to test its reliability in different pathological and risk states, and establish susceptibility in therapeutic procedures. The correlation with invasive functional angiographic tests and the flow mediated dilatation test of peripheral arteries also needs to be validated. We expect the proposed test of vWF inducibility to find its place in clinical practice, i.e. in prevention, prediction and therapy of cardiovascular diseases.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese:
Broj citata:
DOI: 10.1016/j.mehy.2007.03.011
URL cjelovitog teksta:
Google Scholar: Exercise induced von Willebrand Factor release - New model for routine endothelial testing
Upisao u CROSBI: (, 15. Ožu. 2009. u 09:58 sati

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