crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 393785

Časopis

Autori: Gobin, Ivana; Šuša, Milorad; Begić, Gabrijela; Hartland, L. Elizabeth; Dorić, Miljenko
Naslov: Experimental Legionella longbeachae infection in intratracheally inoculated mice
( Experimental Legionella longbeachae infection in intratracheally inoculated mice )
Izvornik: Journal of Medical Microbiology (0022-2615) 58 (2009), 6; 723-730
Vrsta rada: članak
Ključne riječi: legionellosis; lung infection; murine model
( legionellosis; lung infection; murine model )
Sažetak:
This study established an experimental model of replicative Legionella longbeachae infection in A/ J mice. The animals were infected by intratracheal inoculation of 10(3)– 10(9) c.f.u. L. longbeachae serogroup 1 (USA clinical isolates D4968, D4971 and D4973). The inocula of 10(9), 10(8), 10(7) and 10(6) c.f.u. of all tested L. longbeachae serogroup 1 isolates were lethal for A/J mice. Inoculation of 10(5) c.f.u. L. longbeachae caused death in 90% of the animals within 5 days, whilst inoculation of 10(4) c.f.u. caused sporadic death of mice. All animals that received 10(3) c.f.u. bacteria developed acute lower respiratory disease, but were able to clear Legionella from the lungs within 3 weeks. The kinetics of bacterial growth in the lungs was independent of inoculum size and reached a growth peak about 3 logarithms above the initial inoculum at 72 h after inoculation. The most prominent histological changes in the lungs were observed at 48– 72 h after inoculation in the form of a focal, neutrophil-dominant, peribronchiolar infiltration. The inflammatory process did not progress towards the interstitial or alveolar spaces. Immunohistological analyses revealed L. longbeachae serogroup 1 during the early phase of infection near the bronchiolar epithelia and later co-localized with inflammatory cells. BALB/c and C57BL/6 mice strains were also susceptible to infection with all L. longbeachae serogroup 1 strains tested and very similar changes were observed in the lungs of infected animals. These results underline the infection potential of L. longbeachae serogroup 1, which is associated with high morbidity and lethality in mice.
Projekt / tema: 062-0621273-1275
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://jmm.sgmjournals.org/current.shtml
Broj citata:
Altmetric:
DOI: 10.1099/jmm.0.007476-0
URL cjelovitog teksta:
Google Scholar: Experimental Legionella longbeachae infection in intratracheally inoculated mice
Upisao u CROSBI: sandraa@medri.hr (sandraa@medri.hr), 26. Svi. 2009. u 13:26 sati



  Verzija za printanje   za tiskati


upomoc
foot_4