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Pregled bibliografske jedinice broj: 440358

Zbornik radova

Autori: Župan, Gordana; Pilipović, Kristina; Župan, Željko; Frković, Vedran; Dangubić, Boban; Mršić-Pelčić, Jasenka; Šustić, Alan
Naslov: Effects of PPAR-γ agonist pioglitazone on the hippocampus in traumatic brain injured rats
Izvornik: Abstracts of the 13th Congress of the European Federation of Neurological Societies ; u: European Journal of Neurology. Volume 16 (2009) (S3) / Hillbom, Matti ; Schapira, Anthony (ur.). - Firenca : Wiley Blackwell Publishing , 2009. 605-605.
ISSN: 1351-5101
Skup: 13th Congress of the European Federation of Neurological Societies
Mjesto i datum: Firenca, Italija, 12-15.09.2009.
Ključne riječi: traumatic brain injury; enoxaparin; oxidative stress; antioxidant enzymes; COX-2; rats
Sažetak:
Background and aim: Agonist of the peroxisome proliferator-activated receptor-gama (PPAR-γ), pioglitazone, exerts protective role in several experimental models of CNS diseases, such as focal cerebral ischemia, Parkinson's disease, allergic encephalitis, Alzheimer's disease, temporal lobe epilepsy. Its effects in traumatic brain injury (TBI) models are not known. In this study we determined the levels of lipid oxidative damage, the activities of antioxidant enzymes and inflammation parameter expression in the hippocampi of rats with TBI, and treated by a single dose of pioglitazone. Methods: Experiments were performed on adult male Wistar rats. TBI of moderate severity was performed over the left parietal cortex using the lateral fluid percussion brain injury model. Animals were i.p. injected with either pioglitazone (1 ; 3 mg/kg) or vehicle 10 min after TBI. Sham-operated, vehicle-treated animals were used as the control group. Rats were sacrificed 24 hrs after the TBI induction and the hippocampi were processed for spectrophotometric measurements of the thiobarbituric acid reactive substances (TBARS) levels, the superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities or for the analyses of COX-2 expressions. Results: TBI caused the significant increases of the TBARS level, the GSH-Px activity, and COX-2 expression while pioglitazone treatment induced the decrease in lipid oxidative damage and the increases of both antioxidant enzymes’ activities in the ipsilateral hippocampus. TBI-induced COX-2 overexpression was not influenced by pioglitazone administration in mentioned brain structure. Conclusion: Our preliminary results for the first time suggest neuroprotective effects of a single dose of pioglitazone on TBI-induced oxidative hippocampal damage.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 062-0620529-0519, 062-0000000-0220
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www3.interscience.wiley.com/journal/122597193/issue
Upisao u CROSBI: kristina@medri.hr (kristina@medri.hr), 15. Sij. 2010. u 17:11 sati



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