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Pregled bibliografske jedinice broj: 451218

Časopis

Autori: Tota, Marin; Jakovac, Hrvoje; Grebić, Damir; Marinić, Jelena; Broznić, Dalibor; Čanadi-Jurešić, Gordana; Milin, Čedomila; Radošević-Stašić, Biserka
Naslov: Kinetics of tissue iron in experimental autoimmune encephalomyelitis in rats
Izvornik: Biological trace element research (0163-4984) 143 (2011), 1; 332-343
Vrsta rada: članak
Ključne riječi: monophasic experimental autoimmune encephalomyelitis (EAE); chronic relapsing EAE; AO rats; DA rats; inductively coupled plasma spectrometry; iron; brain; spinal cord; liver.
Sažetak:
To elucidate the role of iron in the pathomechanisms of autoimmune CNS disorders we estimated the tissue concentrations of Fe2+ in the brain, spinal cord (SC) and liver in monophasic and chronic relapsing (CR) forms of experimental autoimmune encephalomyelitis (EAE). The diseases were induced in Albino Oxford (AO) and Dark Agouti (DA) strain of rats, by subcutaneous injection of myelin basic protein in complete Freund’s adjuvant (CFA) or by bovine brain homogenate in CFA, respectively. Control rats were treated with CFA or with saline solution. The data obtained by clinical assessment and by inductively coupled plasma spectrometry have shown that in both strains of rats the attacks of disease were followed by high accumulation of iron in the liver (on the 12th post-immunization day in AO rats and on the 12th and 22nd day in DA rats). Simultaneously, in AO rats decreased the concentration of Fe2+ in the brain (during the remission phase) and in the cervical spinal cord (during attack and remission). Similarly, in DA rats the lower iron content was found in cervical spinal cord during the second attack of disease. The data point to regulatory effects of iron and hepatic trace elements regulating mechanisms in the pathogenesis of EAE.
Projekt / tema: 062-0621341-1337, 062-0621341-0061
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://rd.springer.com/article/10.1007/s12011-010-8841-8
Broj citata:
Altmetric:
DOI: 10.1007/s12011-010-8841-8
URL cjelovitog teksta:
Google Scholar: Kinetics of tissue iron in experimental autoimmune encephalomyelitis in rats
Upisao u CROSBI: biserr@medri.hr (biserr@medri.hr), 24. Ožu. 2010. u 09:19 sati



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