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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 458920

Časopis

Autori: Bobinac, Dragica; Spanjol, Josip; Marinović, Marin; Zoričić Cvek, Sanja; Marić, Ivana; Cicvarić, Tedi; Fučkar, Željko; Markić, Dean; Vojniković, Božo
Naslov: Expression of bone morphogenetic proteins, cartilage-derived morphogenetic proteins and related receptors in normal and osteoarthritic human articular cartilage
Izvornik: Collegium antropologicum (0350-6134) 32 (2008), S2; 83-87
Vrsta rada: članak
Ključne riječi: BMP; CDMP; receptors; osteoarthritis; articular cartilage
Sažetak:
Newborn and adult articular cartilage expresses bone (BMPs) and cartilage derived morphogenetic proteins (CDMPs). These morphogenetic proteins act over membrane receptors (BMPRs). We examined the expression pattern of BMP-7, BMP-3, CDMP-1, CDMP-2 and their receptors in adult normal and osteoarthritic, articular, knee cartilage. Immunostaining was carried out using polyclonal antibodies. The expression of BMP-7, -3, CDMP-1, -2 was detected in all layers of normal articular cartilage with the strongest expression in chondrocytes of the transitional layer. BMP-7 and CDMPs expression decreased in osteoarthritic articular cartilage whereas BMP-3 expression was absent. BMPR-IA and BMPR-II were strongly expressed in both normal and osteoarthritic articular cartilage. BMPR-IB was not expressed in osteoarthritic (OA) cartilage. BMPs and CDMPs with intact signalling play an important role in articular cartilage homeostasis, preventing cartilage degeneration.
Projekt / tema: 062-0000000-3559
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=54743
URL cjelovitog teksta:
Google Scholar: Expression of bone morphogenetic proteins, cartilage-derived morphogenetic proteins and related receptors in normal and osteoarthritic human articular cartilage
Upisao u CROSBI: sanja@medri.hr (sanja@medri.hr), 1. Tra. 2010. u 13:40 sati



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