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Pregled bibliografske jedinice broj: 474322

Časopis

Autori: Čačić, Milan; Molnar, Maja; Balić, Tomislav; Draca, Nela; Rajković, Valentina
Naslov: Design and Synthesis of Some Thiazolidin-4-ones Based on (7-Hydroxy-2-oxo-2H-chromen-4-yl) Acetic Acid
Izvornik: Molecules (1420-3049) 14 (2009), 7; 2501-2513
Vrsta rada: članak
Ključne riječi: coumarin; dihydrazides; aromatic Schiff’s bases; N-(2-aryl-4-oxo-thiazolidin- 3-yl)-2-((4-(2-aryl-4-oxo-thiazolidin-3-ylcarbamoyl)-methyl)-2-oxo-2H-chromen-7-yloxy)- acetamides; biological activity
Sažetak:
(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid methyl ester (1) upon reaction with ethyl bromoacetate furnishes (7-ethoxycarbonylmethoxy-2-oxo-2H-chromen-4-yl)- acetic acid methylester (2), which on treatment with 100% hydrazine hydrate yields (7-hydrazinocarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (3). The condensation of compound 3 with different aromatic aldehydes afforded a series of [7-(arylidenehydrazinocarbonylmethoxy)-2-oxo-2H-chromen-4-yl]-acetic acid arylidenehydrazide Schiff’s bases 4a-k. Cyclo-condensation of compounds 4a-k with 2-mercaptoacetic acid in N, N-dimethylformamide in the presence of anhydrous ZnCl2 affords N-(2-aryl-4-oxothiazolidin-3-yl)-2-(4-(2-aryl-4-oxothiazolidin-3-ylcarbamoyl)-methyl)-2- oxo-2H-chromen-7-yloxy)-acetamides 5a-k. Structure elucidation of the products has been accomplished on the basis of elemental analysis, IR, 1H-NMR and 13C-NMR data. Compounds 4a-k and 5a-k will be screened for their antibacterial activity against both Gram-positive and Gram-negative bacteria and the results reported elsewhere in due course.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Prehrambena tehnologija
Puni text rada: 474322.molecules-Design_and_Synthesis_of_Some_Thiazolidin-4-ones_Based_on.pdf (tekst priložen 23. Lip. 2010. u 11:27 sati)
URL Internet adrese: http://www.mdpi.com/1420-3049/14/7/2501/pdf
Broj citata:
Altmetric:
DOI: 10.3390/molecules14072501
URL cjelovitog teksta:
Google Scholar: Design and Synthesis of Some Thiazolidin-4-ones Based on (7-Hydroxy-2-oxo-2H-chromen-4-yl) Acetic Acid
Upisao u CROSBI: mmolnar@ptfos.hr (mmolnar@ptfos.hr), 23. Lip. 2010. u 11:27 sati



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